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Title: The genome sequence of Drosophila melanogaster.

The fly Drosophila melanogaster is one of the most intensively studied organisms in biology and serves as a model system for the investigation of many developmental and cellular processes common to higher eukaryotes, including humans. We have determined the nucleotide sequence of nearly all of the {approximately}120-megabase euchromatic portion of the Drosophila genome using a whole-genome shotgun sequencing strategy supported by extensive clone-based sequence and a high-quality bacterial artificial chromosome physical map. Efforts are under way to close the remaining gaps; however, the sequence is of sufficient accuracy and contiguity to be declared substantially complete and to support an initial analysis of genome structure and preliminary gene annotation and interpretation. The genome encodes {approximately}13,600 genes, somewhat fewer than the smaller Caenorhabditis elegans genome, but with comparable functional diversity.
Publication Date:
OSTI Identifier:
772144
Report Number(s):
LBNL-45518
Journal ID: ISSN 0193-4511; SCEHDK; R&D Project: 80AD; TRN: AH200104%%601
DOE Contract Number:
AC03-76SF00098
Resource Type:
Journal Article
Resource Relation:
Journal Name: Science; Journal Volume: 287; Journal Issue: 5461; Other Information: PBD: 24 Mar 2000
Research Org:
Lawrence Berkeley National Lab., CA (US)
Sponsoring Org:
National Institutes of Health (NIH); Industry (US)
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; ACCURACY; BIOLOGY; CHROMOSOMES; DROSOPHILA; FUNCTIONALS; GENES; NUCLEOTIDES; GENOME DNA SEQUENCE FRUIT FLY DROSOPHILA MELANOGASTER