Cadmium and membrane ion transport in a French urban male population
- National Inst. of Health and Medical Research, Villejuif (France)
- INSERM, Paris (France)
- Social and Sanitary Dept. Labs., Paris (France)
Toxic effects of cadmium upon cell membranes structures and function have been well documented. Experimental studies have shown that cadmium is a potent Na{sup +}-K{sup +} ATPase inhibitor. One report has confirmed these findings with the human Na{sup +}-K{sup +} ATPase. Based on the above observations, several authors have suggested that a Na{sup +}-K{sup +} ATPase-inhibitory action could be involved in health related cadmium toxicity. Therefore, the authors measured hair cadmium and red blood cell Na{sup +}-K{sup +} pump (physiological counterpart of the Na{sup +}-K{sup +} ATPase) in 129 urban caucasian males, without known occupational exposure to cadmium. In addition, four other ion transport pathways were measured in red blood cells. Hair cadmium was considered, as it is known as an indicator of cadmium body burden. A particular emphasis was placed in defining the smoking habits of the subjects since tobacco is known to be the main source of cadmium exposure in the general population.
- OSTI ID:
- 7278713
- Journal Information:
- Bulletin of Environmental Contamination and Toxicology; (United States), Vol. 47:6; ISSN 0007-4861
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CADMIUM COMPOUNDS
MEMBRANE TRANSPORT
ERYTHROCYTES
CHEMICAL ANALYSIS
HAIR
FRANCE
HUMAN POPULATIONS
MEN
TOBACCO SMOKES
AEROSOLS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
COLLOIDS
DEVELOPED COUNTRIES
DISPERSIONS
EUROPE
MALES
MAMMALS
MAN
MATERIALS
ORGANS
POPULATIONS
PRIMATES
RESIDUES
SKIN
SMOKES
SOLS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology