Chronic effects of JP-8 jet-fuel exposure on the lungs. Annual report, 1 Apr 91-1 Apr 92

Technical Report · Thu Apr 23 00:00:00 EDT 1992

OSTI ID:7278678

Witten, M L

This research has resulted in four separate projects. The first was the exposure of Fischer 344 rats to JP-8 jet fuel for 7 or 28 days. This exposure resulted in changes in pulmonary function and lung chemical mediators, specifically Substance P, after 28 days of exposure. The second project dealt with blocking the increase in SP in these rats by a pretreatment regimen with capsaicin before jet fuel exposure. Capsaicin caused a further increase in lung permeability and a million-fold increase in airway sensitivity to histamine after the 7-day jet fuel exposure. The third project dealt with the effects of a 7-day jet fuel exposure in congenic mice who are deficient in the inducibility of the aryl hydrocarbon hydroxylase enzyme. These mice are relatively resistant to the effects of jet fuel-induced lung injury. The fourth project investigated the effects of the jet fuel exposure on secondary organs, specifically the liver, spleen, and kidneys. There were pathological differences in the liver, spleen, and kidneys between the 7-day jet fuel exposure group and baseline controls. However, some of these differences were not apparent in the 28-day exposure group, possibly indicating compensatory mechanisms to the exposure.

• Research Organization: Arizona Univ., Tucson, AZ (United States)
• OSTI ID: 7278678
• Report Number(s): AD-A-250308/4/XAB
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
JET ENGINE FUELS
TOXICITY
LUNGS
SENSITIVITY
CHRONIC EXPOSURE
HISTAMINE
HYDROCARBONS
HYDROXYLASES
KIDNEYS
LIVER
MICE
PEPTIDES
PERMEABILITY
RATS
SPLEEN
AMINES
ANIMALS
AZOLES
BODY
DIGESTIVE SYSTEM
ENZYMES
FUELS
GLANDS
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
MAMMALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXIDOREDUCTASES
PROTEINS
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology