Determination of lipophilicity of chlorinated alicyclic compounds by reversed-phase high performance liquid chromatography

Journal Article · Sat Jan 01 00:00:00 EST 1994 · Journal of Liquid Chromatography; (United States)

DOI:https://doi.org/10.1080/10826079408013474· OSTI ID:7276030

Liu, J; Coats, J R ^[1]; Chambers, J E ^[2]

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1. Iowa State Univ., Ames, IA (United States). Dept. of Entomology
2. Mississippi State Univ., Mississippi State, MS (United States). Coll. of Veterinary Medicine

A RP-HPLC procedure has been developed for measuring the capacity factor (k[prime]) of a series of chlorinated alicyclic compounds. The chromatographic behavior measured on a 4.5 mm i.d. [times] 3.3 cm C-18 column with methanol/water as the mobile phase was related to the volume fraction of methanol ([phi]). A linear relationship was found between log k[prime] and [phi], showing the correlation coefficient [lambda] > 0.99, for each of the 15 chlorinated alicyclic compounds tested. The log k[sub w], the capacity factor obtained by extrapolation of the retention data from binary effluents to 100% water, was chosen as a measure of the solute lipophilicity. Since log k[sub w] is considered as a valuable index of the lipophilicity of a compound, the determined values will be used for the quantitative structure-activity relationship studies of the chlorinated alicyclic compounds.

• OSTI ID: 7276030
• Journal Information: Journal of Liquid Chromatography; (United States), Vol. 17:9; ISSN 0148-3919
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
CHLORINATED ALIPHATIC HYDROCARBONS
LIQUID COLUMN CHROMATOGRAPHY
CHEMICAL PROPERTIES
MASS TRANSFER
SOLUTES
CHROMATOGRAPHY
HALOGENATED ALIPHATIC HYDROCARBONS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
SEPARATION PROCESSES
400102* - Chemical & Spectral Procedures