Sublethal exposure of extracted sediments induces hepatic cellular alterations in Medaka, Oryzias latipes: An assay for testing the presence of carcinogens

Conference · Thu Sep 01 00:00:00 EDT 1988 · Preprints of Papers Presented at National Meeting, Division of Water, Air and Waste Chemistry, American Chemical Society; (USA)

OSTI ID:7267032

Chai, D; Cormier, S M ^[1]

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1. Univ. of Louisville, KY (USA)

Small aquarium fish species and embryos have many positive attributes as test animals. They require little space and therefore, generate less toxic waste especially when coupled with single, short term exposures. In addition to these advantages, Oryzias latipes, the medaka, offers additional benefits. The medakas genetics and biology have been well studied, reproduction can be easily controlled with an appropriate light cycle, embryos mature rapidly and the species has been shown to be sensitive to carcinogens. For these reasons the medaka was selected for these experiments to determine the relative toxicity and carcinogenicity of contaminated sediments via a single, short term exposure. Two known carcinogens, Aflatoxin B{sub 1} (AFB{sub 1}) and Aroclor 1254 (PCB), and six environmental samples were tested. The selection of sediment sampling sites was based on a report generated from the Pittsburgh District Dredged Material Analysis Program. Four sites along the Monogahela River and two on the Ohio River where sampled with an Eckman dredge. The chemical analyses conducted by the Corps have shown the presence of various toxic chemicals including polyaromatic hydrocarbons and heavy metals.

• OSTI ID: 7267032
• Report Number(s): CONF-8909236-; CODEN: ACWCA
• Journal Information: Preprints of Papers Presented at National Meeting, Division of Water, Air and Waste Chemistry, American Chemical Society; (USA), Vol. 28:2; Conference: JAERI/EPA workshop on residual radiation and recycle criteria, St. Michaels, MD (USA), 27-28 Sep 1989; ISSN 0099-7293
• Country of Publication: United States
• Language: English

Related Subjects

54 ENVIRONMENTAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
FISHES
SENSITIVITY
LIVER
PATHOLOGICAL CHANGES
METALS
TOXICITY
OHIO RIVER
WATER POLLUTION
POLYCYCLIC AROMATIC HYDROCARBONS
BIOLOGICAL INDICATORS
BIOASSAY
CARCINOGENS
CHEMICAL ANALYSIS
EMBRYOS
PENNSYLVANIA
SEDIMENTS
ANIMALS
AQUATIC ORGANISMS
AROMATICS
BODY
DIGESTIVE SYSTEM
ELEMENTS
FEDERAL REGION III
GLANDS
HYDROCARBONS
NORTH AMERICA
ORGANIC COMPOUNDS
ORGANS
POLLUTION
RIVERS
STREAMS
SURFACE WATERS
USA
VERTEBRATES
540320* - Environment
Aquatic- Chemicals Monitoring & Transport- (1990-)
560300 - Chemicals Metabolism & Toxicology