Calcium and vitamin D metabolism in spontaneously hypertensive rats
- Univ. of Michigan Medical School, Ann Arbor (USA)
The authors have studied the effect of dietary vitamin D restriction on serum levels of vitamin D metabolites, measured by radioreceptor assay and radioimmunoassay in spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY). Both WKY and SHR were fed a vitamin D-deficient or a vitamin D-supplemented diet beginning at 4 wk of age. In vitamin D-supplemented animals, the serum 1,25-dihydroxycholecalciferol (1,25(OH){sub 2}D{sub 3}) concentration of WKY was similar to the level of SHR. Plasma calcium concentration was not different between WKY and SHR. In animals fed a vitamin D-deficient diet, the serum concentration of 1,25-(OH){sub 2}D{sub 3} of SHR was significantly lower than that of WKY. Plasma 25-hydroxycholecalciferol level was markedly decreased in both WKY and SHR. The SHR, but not the WKY, developed hypocalcemia. Despite hypocalcemia, fasting urinary Ca{sup 2+} excretion of SHR exceeded that of WKY. They conclude that the lower 1,25(OH){sub 2}D{sub 3} level in SHR fed a vitamin D-deficient diet may be due to a defect in the synthesis of 1,25(OH){sub 2}D{sub 3}. The low level of 1,25(OH){sub 2}D{sub 3} is associated with renal wasting of calcium and hypocalcemia in SHR.
- OSTI ID:
- 7266810
- Journal Information:
- American Journal of Physiology; (USA), Vol. 253:4; ISSN 0002-9513
- Country of Publication:
- United States
- Language:
- English
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550201* - Biochemistry- Tracer Techniques