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Title: Evidence for a non-opioid sigma binding site din the guinea-pig myenteric plexus

The presence of a binding site to (+)-(/sup 3/H)SKF 10,047 was demonstrated in a guinea-pig myenteric plexus (MYP) membrane preparation. Specific binding to this receptor was saturable, reversible, linear with protein concentration and consisted of two components, a high affinity site and a low affinity site. Morphine and naloxone 10/sup -4/M were unable to displace (+)-(/sup 3/H)SKF 10,047 binding. Haloperidol, imipramine, ethylketocyclazocine and propranolol were among the most potent compounds to inhibit this specific binding. These results suggest the presence of a non-opioid haloperidol sensitive sigma receptor in the MYP of the guinea-pig.
Authors:
; ; ;
Publication Date:
OSTI Identifier:
7253534
Resource Type:
Journal Article
Resource Relation:
Journal Name: Life Sci.; (United States); Journal Volume: 42:22
Research Org:
JOUVEINAL Laboratoires, Fresnes (France)
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; SYMPATHOMIMETICS; BIOCHEMICAL REACTION KINETICS; RECEPTORS; CELL MEMBRANES; GUINEA PIGS; INTESTINES; TRACER TECHNIQUES; TRITIUM COMPOUNDS; ANIMALS; AUTONOMIC NERVOUS SYSTEM AGENTS; BODY; CELL CONSTITUENTS; DIGESTIVE SYSTEM; DRUGS; GASTROINTESTINAL TRACT; ISOTOPE APPLICATIONS; KINETICS; LABELLED COMPOUNDS; MAMMALS; MEMBRANE PROTEINS; MEMBRANES; ORGANIC COMPOUNDS; ORGANS; PROTEINS; REACTION KINETICS; RODENTS; VERTEBRATES 550201* -- Biochemistry-- Tracer Techniques