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Title: Altered biodistribution of Ga-67 by intramuscular gold salts

The authors observed a deviation from the normal scintigraphic pattern of Ga-67 citrate biodistribution. An 8-year-old black girl with juvenile rheumatoid arthritis, who had been treated with intramuscular injections of gold salts, had a Ga-67 study as part of her workup. The study demonstrated no hepatic uptake, but showed elevated skeletal and renal activity. This characteristic biodistribution of Ga-67 may be due to inhibition of lysosomal enzymes by gold and/or to accumulation of gold in lysosomes. To study these possibilities, the authors reviewed the mechanisms of Ga-67 localization and gold metabolism. Alteration of the Ga-67 citrate scintigraphic pattern due to earlier treatment with gold salts has not been reported previously.
Authors:
;  [1]
  1. (Chicago Osteopathic Medical Center, IL (USA))
Publication Date:
OSTI Identifier:
7244570
Resource Type:
Journal Article
Resource Relation:
Journal Name: Clinical Nuclear Medicine; (USA); Journal Volume: 14:11
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; GALLIUM 67; TISSUE DISTRIBUTION; GOLD; METABOLISM; RHEUMATIC DISEASES; DIAGNOSIS; CHILDREN; CITRATES; LYSOSOMES; SCINTISCANNING; AGE GROUPS; BETA DECAY RADIOISOTOPES; CARBOXYLIC ACID SALTS; CELL CONSTITUENTS; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; DISTRIBUTION; ELECTRON CAPTURE RADIOISOTOPES; ELEMENTS; GALLIUM ISOTOPES; INTERMEDIATE MASS NUCLEI; ISOTOPES; METALS; NUCLEI; ODD-EVEN NUCLEI; ORGANOIDS; RADIOISOTOPE SCANNING; RADIOISOTOPES; SKELETAL DISEASES; TRANSITION ELEMENTS 550601* -- Medicine-- Unsealed Radionuclides in Diagnostics