Ultrastructural pathology and immunohistochemistry of mustard gas lesion

Technical Report · Thu May 13 00:00:00 EDT 1993

OSTI ID:7239934

Petrali, J P; Oglesby, S B; Hamilton, T A; Mills, K R

The ultrastructural pathology of sulfur mustard gas (HD) skin toxicity has been characterized for several in vivo and in vitro model systems. In animal models, the pathology involves the latent lethal targeting of skin basal cells, a disabling of hemidesmosomes and a progressive edema of the lamina lucida, all of which contribute to the formation of characteristic microblisters at the dermal-epidermal junction. However, the effects of HD toxicity on structural proteins of extracellular domains of the dermal-epidermal junction have not been elucidated. We are beginning an immunohistochemical study of these domains in the hairless guinea pig and summarize here the time course effects of HD of three structural proteins: bullous pemphigoid antigen, laminin and Type IV collagen. The results of this combined ultrastructural and immunohistochemical study indicate that proteins of extracellular matrices of the basement membrane are antigenically altered during the development of HD-induced skin pathology and may contribute to the formation of microblisters.

• Research Organization: Army Medical Research Inst. of Chemical Defense, Aberdeen Proving Ground, MD (United States)
• OSTI ID: 7239934
• Report Number(s): AD-P-008753/6/XAB
• Resource Relation: Other Information: This article is from 'Proceedings of the Medical Defense Bioscience Review (1993) Held in Baltimore, Maryland on 10-13 May 1993. Volume 1, AD-A275 667, p15-20
• Country of Publication: United States
• Language: English

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