Assignment of the norepinephrine transporter protein (NET1) locus to chromosome 16

Journal Article · Wed Dec 01 00:00:00 EST 1993 · Genomics; (United States)

DOI:https://doi.org/10.1016/S0888-7543(05)80375-1· OSTI ID:7200973

Gelernter, J; Kruger, S ^[1]; Kidd, K K; Pakstis, A J; Pacholczyk, T ^[2]; Sparkes, R S ^[3]; Amara, S ^[4]

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1. West Haven VA Medical Center, CT (United States)
2. Yale Univ. School of Medicine, New Haven, CT (United States)
3. UCLA Health Sciences Center, Los Angeles, CA (United States)
4. Oregon Health Sciences Univ., Portland, OR (United States)

The norepinephrine transporter protein (NET) is the presynaptic reuptake site for norepinephrine and a site of action for several drugs with CNS effects, some of which are therapeutically useful and some of which are drugs of abuse. The authors used PCR with a somatic cell hybrid panel to obtain a provisional assignment to chromosome 16. They then typed a genetic polymorphism at the NET1 locus in three large multigenerational families and used linkage analysis to confirm the preliminary assignment and to refine the localization to 16q, near the HP locus. Finally, they typed the NET1 RFLP, on the CEPH families and the additional linkage data localized NET1 to 16q13-q21, flanked by D16S71 (centromerically) and HP (telomerically). 11 refs., 2 tabs.

• OSTI ID: 7200973
• Journal Information: Genomics; (United States), Vol. 18:3; ISSN 0888-7543
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
HUMAN CHROMOSOME 16
GENETIC MAPPING
NORADRENALINE
MEMBRANE TRANSPORT
PORINS
GENES
ADRENAL HORMONES
AUTONOMIC NERVOUS SYSTEM AGENTS
CARDIOTONICS
CARDIOVASCULAR AGENTS
CHROMOSOMES
DRUGS
HORMONES
HUMAN CHROMOSOMES
MAPPING
MEMBRANE PROTEINS
NEUROREGULATORS
ORGANIC COMPOUNDS
PROTEINS
SYMPATHOMIMETICS
550400* - Genetics