Lead distribution in rats repeatedly treated with low doses of lead acetate
- Univ. de Montreal, Quebec (Canada)
Male Sprague-Dawley rats were treated with ip injections of lead acetate (10 and 20 mg/kg) at intervals 1, 2, 4, 8, 12, 16, 20, and 24 weeks. Eight rats from each specified injection group were sacrificed 48 hr after the end of each treatment. Lead was determined in whole blood, plasma, plasma filtrate, saliva, urine, feces, brain, salivary glands, liver, kidney, testes, femur, and fur. In the liver, the concentrations of lead fluctuated; in the salivary glands and testes, lead levels were low. In the bone, the kidney, and the brain, lead accumulated steadily and reached high levels in bone and renal tissues, but remained low in the brain. Correlation analysis showed a reciprocal relationship between blood-lead and kidney-lead in the rats treated with 10 mg lead acetate/kg. In the rats treated with 20 mg lead acetate/kg, urine-lead was correlated to kidney-lead. In both groups of treated rats, fur-lead was correlated to kidney-lead.
- OSTI ID:
- 7194172
- Journal Information:
- Environmental Research; (USA), Vol. 48:2; ISSN 0013-9351
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
LEAD COMPOUNDS
TISSUE DISTRIBUTION
ACETATES
BLOOD
BLOOD PLASMA
BODY FLUIDS
CORRELATIONS
FECES
HAIR
INTRAPERITONEAL INJECTION
KIDNEYS
LIVER
RATS
SALIVARY GLANDS
SKELETON
TESTES
URINE
ANIMALS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
CARBOXYLIC ACID SALTS
DIGESTIVE SYSTEM
DISTRIBUTION
GLANDS
GONADS
INJECTION
INTAKE
MALE GENITALS
MAMMALS
MATERIALS
ORGANS
RODENTS
SKIN
VERTEBRATES
WASTES
560300* - Chemicals Metabolism & Toxicology