sup 14 C-urea breath test for the detection of Helicobacter pylori
- McMaster Univ., Hamilton, Ontario (Canada)
The high urease activity of Helicobacter pylori can be used to detect this bacterium by noninvasive breath tests. We have developed a {sup 14}C-urea breath test which uses 5 microCi {sup 14}C with 50 mg nonradioactive urea. Breath samples are collected at baseline and every 30 min for 2 h. Our study compared the outcome of the breath test to the results of histology and culture of endoscopically obtained gastric biopsies in 84 patients. The breath test discriminated well between the 50 positive patients and the 34 patients negative for Helicobacter pylori: the calculated sensitivity was 100%, specificity 88%, positive predictive value 93%, and negative predictive value 100%. Treatment with bismuth subsalicylate and/or ampicillin resulted in lower counts of exhaled {sup 14}CO{sub 2} which correlated with histological improvement in gastritis. The {sup 14}C-urea breath test is a better gold standard for the detection of Helicobacter pylori than histology and/or culture.
- OSTI ID:
- 7192806
- Journal Information:
- American Journal of Gastroenterology; (USA), Vol. 85:4; ISSN 0002-9270
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BACTERIAL DISEASES
DIAGNOSIS
UREASE
ENZYME ACTIVITY
BACTERIA
BIOPSY
CARBON 14 COMPOUNDS
FORECASTING
MAN
PATIENTS
TRACER TECHNIQUES
UREA
AMIDES
AMIDINASES
ANIMALS
CARBONIC ACID DERIVATIVES
DIAGNOSTIC TECHNIQUES
DISEASES
ENZYMES
HYDROLASES
INFECTIOUS DISEASES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MICROORGANISMS
NON-PEPTIDE C-N HYDROLASES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PRIMATES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics