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Title: D-A and D-2 dopamine receptor function in the rabbit retina: a model for the central nervous system

Studies were done investigating the effect of the synaptic concentration of the transmitter DA, modified by changes in the frequency of electrical field stimulation and by the DA uptake inhibitor nomifensine, on the modulation of /sup 3/H-DA release by D-2 DA autoreceptors and by melatonin receptor sites. At lower synaptic concentrations of the transmitter dopamine, D-2 DA receptor agonists were more potent, while antagonists were more potent when the synaptic concentration of transmitter was higher. The potency of melatonin to inhibit DA release was not altered by the frequency of field stimulation of by frequency-dependent changes in the synaptic concentration of the transmitter.
Authors:
Publication Date:
OSTI Identifier:
7191758
Resource Type:
Thesis/Dissertation
Resource Relation:
Other Information: Thesis (Ph. D.)
Publisher:
Northwestern Univ.,Evanston, IL
Research Org:
Northwestern Univ., Evanston, IL (USA)
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; DOPAMINE; RECEPTORS; BIOLOGICAL FUNCTIONS; BIOELECTRICITY; BIOLOGICAL MODELS; CENTRAL NERVOUS SYSTEM; MELATONIN; RABBITS; RETINA; TRACER TECHNIQUES; TRITIUM COMPOUNDS; AMINES; ANIMALS; AROMATICS; AUTONOMIC NERVOUS SYSTEM AGENTS; AZAARENES; AZOLES; BODY; BODY AREAS; CARDIOTONICS; CARDIOVASCULAR AGENTS; DRUGS; ELECTRICITY; EYES; FACE; FUNCTIONS; HEAD; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; INDOLES; ISOTOPE APPLICATIONS; LABELLED COMPOUNDS; MAMMALS; MEMBRANE PROTEINS; NERVOUS SYSTEM; NEUROREGULATORS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PHENOLS; POLYPHENOLS; PROTEINS; PYRROLES; SENSE ORGANS; SYMPATHOMIMETICS; TRYPTAMINES; VERTEBRATES 550201* -- Biochemistry-- Tracer Techniques