Radiation therapy for early glottic cancer (T1N0M0): II. Prospective randomized study concerning radiation field
- Center for Adult Diseases, Osaka (Japan)
A prospective randomized study to determine the effect of radiation field on the local control of early glottic cancer was performed. From May 1982 through December 1985, a total of 87 patients with early glottic cancer (T1N0M0) were treated at our department with an individualized wedge filter technique using a shell to improve the dose distribution and immobilization during radiotherapy with 4 MV X ray. Patients were randomly allocated to either treatment group A (radiation field size: 5 x 5 cm2) or B (6 x 6 cm2) using bilateral parallel opposed portals. Total radiation dose administered was 60 Gy in 30 fractions over a 6-week period. The 3-year recurrence-free survival rates were 93% in group A and 96% in group B (no significant difference). Comparison with historical control showed that both arms achieved better results. These results were mainly due to the improved local control of whole-length lesions of single vocal cords. Acute mucosal reaction (p less than 0.05) and persistent arytenoid edema lasting more than 6 months (p less than 0.02) were more frequently observed in group B than in group A. It is concluded that the critical factor in getting optimal results in the treatment of early glottic cancer is careful attention to the technique of treatment.
- OSTI ID:
- 7190805
- Journal Information:
- International Journal of Radiation Oncology, Biology and Physics; (USA), Vol. 18:1; ISSN 0360-3016
- Country of Publication:
- United States
- Language:
- English
Similar Records
Single Vocal Cord Irradiation: Image Guided Intensity Modulated Hypofractionated Radiation Therapy for T1a Glottic Cancer: Early Clinical Results
Cancer of the glottis: prognostic factors in radiation therapy
Related Subjects
LARYNX
NEOPLASMS
RADIOTHERAPY
FRACTIONATED IRRADIATION
RADIATION DOSE DISTRIBUTIONS
RADIATION DOSES
RADIATION INJURIES
X RADIATION
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DISEASES
DOSES
ELECTROMAGNETIC RADIATION
INJURIES
IONIZING RADIATIONS
IRRADIATION
MEDICINE
NUCLEAR MEDICINE
RADIATION EFFECTS
RADIATIONS
RADIOLOGY
RESPIRATORY SYSTEM
THERAPY
550603* - Medicine- External Radiation in Therapy- (1980-)