Adult-onset nemaline rods in a patient treated for suspected dermatomyositis: study with two-dimensional electrophoresis
Journal Article
·
· Arch. Neurol.; (United States)
A 65-year-old woman with progressive muscle weakness and a diffuse rash of three years' duration was examined. Muscle tissue was studied with histochemical techniques, phase-contrast microscopy, electron microscopy, and two-dimensional electrophoresis. Histochemical studies showed numerous nemaline rods, with a normal ratio of types I and II fibers. Two-dimensional electrophoresis revealed abnormalities in the myosin light chain and tropomyosin protein patterns when compared with normal and diseased muscle biopsy samples, including those from two patients with adult-onset dermatomyositis.
- Research Organization:
- Univ. of Illinois, Chicago
- DOE Contract Number:
- W-31-109-ENG-38
- OSTI ID:
- 7190532
- Journal Information:
- Arch. Neurol.; (United States), Vol. 38
- Country of Publication:
- United States
- Language:
- English
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