Radioprotection of mice with interleukin-1: Relationship to the number of erythroid and granulocyte-macrophage colony-forming cells
- American Red Cross, Rockville, MD (USA)
This report presents the results of an investigation of changes in the number of erythroid and granulocyte-macrophage colony-forming cells (GM-CFC) that had occurred in tissues of normal B6D2F1 mice 20 h after administration of a radioprotective dose (150 ng) of human recombinant interleukin-1 (rIL-1). Neutrophilia in the peripheral blood and changes in the tissue distribution of GM-CFC demonstrated that cells were mobilized from the bone marrow in response to rIL-1 injection. For example, 20 h after rIL-1 injection marrow GM-CFC numbers were 80% of the numbers in bone marrow from saline-injected mice. Associated with this decrease there was a twofold increase in the number of peripheral blood and splenic GM-CFC. Also, as determined by hydroxyurea injection, there was an increase in the number of GM-CFC in S phase of the cell cycle in the spleen, but not in the bone marrow. Data in this report suggest that when compared to the spleen, stimulation of granulopoiesis after rIL-1 injection is delayed in the bone marrow. Also, the earlier recovery of GM-CFC in the bone marrow of irradiated mice is not dependent upon an increase in the number of GM-CFC at the time of irradiation.
- OSTI ID:
- 7189743
- Journal Information:
- Radiation Research; (USA), Vol. 121:2; ISSN 0033-7587
- Country of Publication:
- United States
- Language:
- English
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LYMPHOKINES
RADIOSENSITIVITY EFFECTS
MACROPHAGES
TISSUE DISTRIBUTION
BONE MARROW
COLONY FORMATION
MICE
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BODY
CONNECTIVE TISSUE CELLS
DISTRIBUTION
GROWTH FACTORS
HEMATOPOIETIC SYSTEM
MAMMALS
MITOGENS
ORGANIC COMPOUNDS
ORGANS
PHAGOCYTES
PROTEINS
RODENTS
SOMATIC CELLS
TISSUES
VERTEBRATES
560152* - Radiation Effects on Animals- Animals