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Title: Direct enhancement by cigarette smoke of asbestos fiber penetration and asbestos-induced epithelial proliferation in rat tracheal explants

Abstract

Tracheal explants from Sprague-Dawley rats were briefly exposed to cigarette smoke or air (control) and then to amosite asbestos. Asbestos fibers in or under the tracheal epithelium were counted and extent of hyperplastic lesions was ascertained at 24 hours, 72 hours, and 1 week after exposure. Smoke-exposed cultures showed significantly greater numbers of fibers in the epithelium and greater proliferative activity compared to findings in cultures not exposed to smoke. These observations indicate that very short exposure to cigarette smoke can directly affect the response of the epithelium to asbestos fibers and that smoke exposure need not be concurrent with asbestos exposure for such event to occur. These reactions may play a role in the greater incidences of lung cancer and asbestosis seen in asbestos-exposed workers who smoke.

Authors:
; ; ;
Publication Date:
Research Org.:
Univ. of British Columbia, Vancouver (Canada)
OSTI Identifier:
7189297
Resource Type:
Journal Article
Journal Name:
JNCI, J. Natl. Cancer Inst.; (United States)
Additional Journal Information:
Journal Volume: 80:7
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ASBESTOS; TOXICITY; EPITHELIUM; PERMEABILITY; TOBACCO SMOKES; BIOLOGICAL EFFECTS; CELL DIVISION; RATS; TRACHEA; TRANSPLANTS; AEROSOLS; ANIMAL TISSUES; ANIMALS; BODY; COLLOIDS; DISPERSIONS; MAMMALS; RESIDUES; RESPIRATORY SYSTEM; RODENTS; SMOKES; SOLS; TISSUES; VERTEBRATES; 560300* - Chemicals Metabolism & Toxicology

Citation Formats

Hobson, J, Gilks, B, Wright, J, and Churg, A. Direct enhancement by cigarette smoke of asbestos fiber penetration and asbestos-induced epithelial proliferation in rat tracheal explants. United States: N. p., 1988. Web. doi:10.1093/jnci/80.7.518.
Hobson, J, Gilks, B, Wright, J, & Churg, A. Direct enhancement by cigarette smoke of asbestos fiber penetration and asbestos-induced epithelial proliferation in rat tracheal explants. United States. https://doi.org/10.1093/jnci/80.7.518
Hobson, J, Gilks, B, Wright, J, and Churg, A. 1988. "Direct enhancement by cigarette smoke of asbestos fiber penetration and asbestos-induced epithelial proliferation in rat tracheal explants". United States. https://doi.org/10.1093/jnci/80.7.518.
@article{osti_7189297,
title = {Direct enhancement by cigarette smoke of asbestos fiber penetration and asbestos-induced epithelial proliferation in rat tracheal explants},
author = {Hobson, J and Gilks, B and Wright, J and Churg, A},
abstractNote = {Tracheal explants from Sprague-Dawley rats were briefly exposed to cigarette smoke or air (control) and then to amosite asbestos. Asbestos fibers in or under the tracheal epithelium were counted and extent of hyperplastic lesions was ascertained at 24 hours, 72 hours, and 1 week after exposure. Smoke-exposed cultures showed significantly greater numbers of fibers in the epithelium and greater proliferative activity compared to findings in cultures not exposed to smoke. These observations indicate that very short exposure to cigarette smoke can directly affect the response of the epithelium to asbestos fibers and that smoke exposure need not be concurrent with asbestos exposure for such event to occur. These reactions may play a role in the greater incidences of lung cancer and asbestosis seen in asbestos-exposed workers who smoke.},
doi = {10.1093/jnci/80.7.518},
url = {https://www.osti.gov/biblio/7189297}, journal = {JNCI, J. Natl. Cancer Inst.; (United States)},
number = ,
volume = 80:7,
place = {United States},
year = {Wed Jun 01 00:00:00 EDT 1988},
month = {Wed Jun 01 00:00:00 EDT 1988}
}