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Title: Concentration of erythrocyte-based magnetic carriers in the bloodstream

The writers postulated that magnetic erythrocytes (ME), injected into the bloodstream, may be concentrated in an assigned region of the vascular bed with the aid of the field of a permanent magnet. To test this hypothesis, erythrocytes ''loaded'' with colloidal magnetite were used, and concentrated in experiments in vitro and in vivo. For the experiments in vivo ME were labeled with sodium pertechnetate (Na /SUP 99n/ TcO4) was estimated in ME with a Rackgamma 1270 counter by determining radioactivity in the ME suspension and in the supernatant. For the experiment in vivo, a midline laparotomy was performed on a dog weighing 14 kg under intravenous hexobarbital anesthesia. The distribution of ME was recorded by means of a gamma-camera.
Authors:
; ; ; ; ;
Publication Date:
OSTI Identifier:
7189130
Resource Type:
Journal Article
Resource Relation:
Journal Name: Bull. Exp. Biol. Med. (Engl. Transl.); (United States); Journal Volume: 100:12
Research Org:
Institute of Experimental Cardiology, Acad. of Med. Sci.
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; BLOOD VESSELS; MAGNETIC FIELDS; TRACER TECHNIQUES; ERYTHROCYTES; BIOLOGICAL LOCALIZATION; BLOOD CIRCULATION; MAGNETIC MATERIALS; BIOLOGICAL ACCUMULATION; DOGS; IN VITRO; IN VIVO; LABELLED COMPOUNDS; MAGNETIC PROPERTIES; MAGNETITE; SODIUM COMPOUNDS; TECHNETATES; TECHNETIUM 99; ALKALI METAL COMPOUNDS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; CARDIOVASCULAR SYSTEM; CHALCOGENIDES; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; IRON COMPOUNDS; IRON ORES; IRON OXIDES; ISOMERIC TRANSITION ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; MAMMALS; MATERIALS; MINERALS; NUCLEI; ODD-EVEN NUCLEI; ORES; ORGANS; OXIDE MINERALS; OXIDES; OXYGEN COMPOUNDS; PHYSICAL PROPERTIES; RADIOISOTOPES; REFRACTORY METAL COMPOUNDS; TECHNETIUM COMPOUNDS; TECHNETIUM ISOTOPES; TRANSITION ELEMENT COMPOUNDS; VERTEBRATES; YEARS LIVING RADIOISOTOPES 550301* -- Cytology-- Tracer Techniques