Long-term consequences of exposure to ozone. I. Lung collagen content

Journal Article · Sun Jan 01 00:00:00 EST 1984 · Toxicol. Appl. Pharmacol.; (United States)

DOI:https://doi.org/10.1016/0041-008X(84)90254-0· OSTI ID:7188729

Last, J A; Reiser, K M; Tyler, W S; Rucker, R B

Lung collagen content of rats and monkeys (Macaca fascicularis) exposed to ozone for 1 to 13 weeks and for 1 year, respectively, was quantified by measurement of 4-hydroxyproline in hydrolysates of whole lungs. In addition, ratios of type I to type III collagen in the lungs of the same monkeys were also evaluated by cyanogen bromide peptide mapping techniques. We observed elevated levels of collagen in lungs of both species of animals exposed to ozone. We conclude that elevations in collagen synthesis rates in lungs of rats and monkeys acutely exposed to high levels of ozone are reflected by corresponding increases in lung collagen content over subchronic and chronic time frames. Preliminary results on young rats also suggest that removal of rats from atmospheres containing ozone does not cause reversal of such increases in lung collagen content. To the contrary, recovery periods of up to 6 weeks seem to exacerbate the observed increases in lung collagen content.

• Research Organization: California Primate Research Center, Davis
• OSTI ID: 7188729
• Journal Information: Toxicol. Appl. Pharmacol.; (United States), Vol. 72:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
LUNGS
PATHOLOGICAL CHANGES
OZONE
BIOLOGICAL EFFECTS
CHRONIC EXPOSURE
AMINO ACID SEQUENCE
COLLAGEN
DOSE-RESPONSE RELATIONSHIPS
FIBROSIS
MACACUS
RATS
ANIMALS
BODY
MAMMALS
MOLECULAR STRUCTURE
MONKEYS
ORGANIC COMPOUNDS
ORGANS
PRIMATES
PROTEINS
RESPIRATORY SYSTEM
RODENTS
SCLEROPROTEINS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)