Validation of a simple isotopic technique for the measurement of global and separated renal function
Schlegel and Gates described an isotopic method for the measurement of global and separated glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) based on the determination by scintillation camera of the fraction of the injected dose (99mTc-DTPA-(/sup 131/I)hippuran) present in the kidneys 1-3 min after its administration. This method requires counting of the injected dose and attenuation correction, but no blood or urine sampling. We validated this technique by the simultaneous infusion of inulin and para-amino hippuric acid (PAH) in patients with various levels of renal function (anuric to normal). To better define individual renal function we studied 9 kidneys in patients either nephrectomized or with a nephrostomy enabling separated function measurement. A good correlation between inulin, PAH clearance, and isotopic GFR-ERPF measurement for both global and separate renal function was observed.
- Research Organization:
- State Univ. of Liege, Belgium
- OSTI ID:
- 7188057
- Journal Information:
- Uremia Invest.; (United States), Vol. 2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
RENAL CLEARANCE
TRACER TECHNIQUES
DTPA
HIPPURAN
HIPPURIC ACID
INULIN
IODINE 131
KIDNEYS
SCINTILLATION COUNTING
TECHNETIUM 99
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOHYDRATES
CARBOXYLIC ACIDS
CHELATING AGENTS
CLEARANCE
CONTRAST MEDIA
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DRUGS
EXCRETION
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
POLYSACCHARIDES
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
SACCHARIDES
TECHNETIUM ISOTOPES
YEARS LIVING RADIOISOTOPES
551001* - Physiological Systems- Tracer Techniques