Chronobiological characteristics of the action of thyroxine of reproduction of Ehrlich's Ascites Tumor cells

Journal Article · Wed May 01 00:00:00 EDT 1985 · Bull. Exp. Biol. Med. (Engl. Transl.); (United States)

OSTI ID:7166066

Stepanenko, V A; Romanov, Y A

This paper studies the action of thyroxine on cell proliferation in a hyperdiploid strain of Ehrlich's Ascites Tumor (EAT) depending on clock time. Five albino mice were given an injection of tritium-thymidine in a dose of 0.5 u Ci/g body weight (specific radioactivity 4.1 Ci/mmole) one hour before sacrifice. On autoradiographs from each animal, during examination of 3000-5000 cells, the number of dividing and DNA-synthesizing cells was counted and mitotic index and radioactive index were calculated and expressed in promille. Parameters method and the results were subjected to statistical analysis by the Fisher-Student method. Differences were considered significant at the P less than 0.05 level.

• Research Organization: NI. Pirogov Second Moscow Medical Institute
• OSTI ID: 7166066
• Journal Information: Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Vol. 98:12
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ASCITES TUMOR CELLS
CELL PROLIFERATION
RADIORECEPTOR ASSAY
MITOGENS
BIOLOGICAL EFFECTS
THYROXINE
AUTORADIOGRAPHY
BIOSYNTHESIS
DNA
GROWTH
LABELLED COMPOUNDS
MICE
MITOSIS
MITOTIC INDEX
STIMULATION
THYMIDINE
TIME DEPENDENCE
TRITIUM COMPOUNDS
AMINO ACIDS
ANIMAL CELLS
ANIMALS
AZINES
CARBOXYLIC ACIDS
CELL DIVISION
HETEROCYCLIC COMPOUNDS
HORMONES
ISOTOPE APPLICATIONS
MAMMALS
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PEPTIDE HORMONES
PYRIMIDINES
RIBOSIDES
RODENTS
SYNTHESIS
THYROID HORMONES
TRACER TECHNIQUES
TUMOR CELLS
VERTEBRATES
550301* - Cytology- Tracer Techniques