Testing systems for biologic markers of genotoxic exposure and effect
Conference
·
OSTI ID:7164135
Societal interest in genotoxicity stems from two concerns: the fear of carcinogenesis secondary to somatic mutation; and the fear of birth defects and decreasing genetic fitness secondary to heritable mutation. There is a pressing need to identify agents that can cause these effects, to understand the underlying dose-response relationships, to identify exposed populations, and to estimate both the magnitude of exposure and the risk of adverse health effects in such populations. Biologic markers refer either to evidence in surrogate organisms, or to the expressions of exposure and effect in human populations. 21 refs.
- Research Organization:
- Lawrence Livermore National Lab., CA (USA)
- DOE Contract Number:
- W-7405-ENG-48
- OSTI ID:
- 7164135
- Report Number(s):
- UCRL-95692; CONF-8610186-1; ON: DE87003242
- Resource Relation:
- Conference: 9. symposium on statistics and the environment risk assessment and public policy, Washington, DC, USA, 27 Oct 1986
- Country of Publication:
- United States
- Language:
- English
Similar Records
Elevated somatic mutations at the glycophorin a (GPA) locus are associated with PAH exposure in Finnish iron foundry workers
Genetic dissection of bioenerrgy traits in sorghum
Elevated levels of somatic mutation of the glycophorin A locus in cancer patients: Relevance for incidence of secondary cancer
Journal Article
·
Wed Oct 01 00:00:00 EDT 1997
· Environmental and Molecular Mutagenesis
·
OSTI ID:7164135
Genetic dissection of bioenerrgy traits in sorghum
Technical Report
·
Fri Jun 15 00:00:00 EDT 2012
·
OSTI ID:7164135
+3 more
Elevated levels of somatic mutation of the glycophorin A locus in cancer patients: Relevance for incidence of secondary cancer
Journal Article
·
Thu Sep 01 00:00:00 EDT 1994
· American Journal of Human Genetics
·
OSTI ID:7164135