Effect of acute exposure to ozone on heart rate and blood pressure of the conscious rat

Journal Article · Sun Dec 01 00:00:00 EST 1985 · Environ. Res.; (United States)

OSTI ID:7163782

Uchiyama, I; Simomura, Y; Yokoyama, E

Electrocardiogram and arterial blood pressure in conscious and unrestrained rats of various ages were recorded during a 3-hr exposure to filtered air or 1 ppm ozone (O/sub 3/). In general, heart rate and mean arterial blood pressure of rats significantly decreased during exposure to O/sub 3/, whereas these functional parameters remained almost stable during exposure to filtered air. Heart rate usually reached a plateau during the exposure to O/sub 3/. Additionally, PR interval and QRS complex significantly increased and premature atrial contraction and incomplete A-V block were frequently observed during the exposure to O/sub 3/. These circulatory effects of O/sub 3/ were more markedly manifested by rats 11 weeks old than either those 8 or 4 weeks old. On the other hand, no significant difference in the circulatory responses was observed between male and female rats. These circulatory effects of O/sub 3/ may be significant from the viewpoint of health effects, although its mechanisms remain unsolved.

• Research Organization: Institute of Public Health, Tokyo, Japan
• OSTI ID: 7163782
• Journal Information: Environ. Res.; (United States), Vol. 38:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
HEART
DYNAMIC FUNCTION STUDIES
OZONE
TOXICITY
ACUTE EXPOSURE
AGE DEPENDENCE
BLOOD PRESSURE
RATS
ANIMALS
BODY
CARDIOVASCULAR SYSTEM
MAMMALS
ORGANS
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology