Localization of the gene for the ciliary neutrotrophic factor receptor (CNTFR) to human chromosome 9
Journal Article
·
· Genomics; (United States)
- Eleanor Roosevelt Institute, Denver, CO (United States) Univ. of Colorado Health Science Center, Denver, CO (United States)
- Brown Univ., Providence, RI (United States)
Ciliary neurotrophic factor (CNTF) has recently been found to be important for the survival of motor neurons and has shown activity in animal models of amyotrophic lateral sclerosis (ALS). CNTF therefore holds promise as a treatment for ALS, and it and its receptor (CNTFR) are candidates for a gene involved in familial ALS. The CNTFR gene was mapped to chromosome 9 by PCR on a panel of human/CHO somatic cell hybrids and localized to 9p13 by PCR on a panel of radiation hybrids. 18 ref., 1 fig., 2 tabs.
- OSTI ID:
- 7162982
- Journal Information:
- Genomics; (United States), Vol. 17:3; ISSN 0888-7543
- Country of Publication:
- United States
- Language:
- English
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