Decreased levels of muscarinic receptors in bladders from the alcohol preferring rat line
- Temple Univ., Philadelphia, PA (United States)
- State Alcohol Co., Helsinki (Finland)
The B{sub max} for ({sup 3}H)QNB binding in the bladders of alcohol preferring (AA) rats was only approximately 60% of that in the alcohol non-preferring (ANA) rats. No significant change in B{sub max} for ({sup 3}H)QNB binding in bladder was observed between alcohol insensitive (AT) and alcohol sensitive (ANT) rats. No significant change in K{sub d} for ({sup 3}H)QNB binding in bladder was observed between the four different rat lines studied. Therefore, alcohol preference but not sensitivity is associated with a decrease in muscarinic receptor density in the rat bladder. Because all of the rats used in this study were ethanol-naive, the decrease in muscarinic receptor density in the bladders of alcohol preferring rats is associated genetic factors inherent to this rat line. Further studies are needed to determine if these observations are tissue specific or specific to the m2 subtype, which predominates in the rat bladder.
- OSTI ID:
- 7159163
- Journal Information:
- Life Sciences; (United States), Vol. 51:13; ISSN 0024-3205
- Country of Publication:
- United States
- Language:
- English
Similar Records
Muscarinic receptor binding and muscarinic receptor-mediated inhibition of adenylate cyclase in rat brain myelin
Alkylating derivative of oxotremorine interacts irreversibly with the muscarinic receptor
Related Subjects
ETHANOL
BIOLOGICAL EFFECTS
PARASYMPATHOMIMETICS
RECEPTORS
BIOCHEMICAL REACTION KINETICS
BLADDER
RATS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
ALCOHOLS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BODY
DRUGS
HYDROGEN COMPOUNDS
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
KINETICS
MAMMALS
MEMBRANE PROTEINS
ORGANIC COMPOUNDS
ORGANS
PROTEINS
REACTION KINETICS
RODENTS
URINARY TRACT
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology