Enhanced histamine release from lung mast cells of guinea pigs exposed to sulfuric acid aerosols
- National Inst. for Environmental Studies, Ibaraki (Japan)
- Univ. School of Medicine, Tokyo (Japan)
To clarify the relationship between air pollution and mast cell response, the effects of sulfuric acid aerosols on histamine release from lung mast cells of guinea pigs were investigated. Guinea pigs were exposed to 0.3, 1.0 and 3.2 mg/m{sup 3} sulfuric acid (H{sub 2}SO{sub 4}) aerosols or 4 ppm nitrogen dioxide (NO{sub 2}) for 2 and 4 weeks. After the exposure, lung mast cell suspensions were isolated by collagenase treatment and antigen- or A23187-induced histamine release was measured. Antigen-induced histamine release from mast cells was significantly enhanced by the exposure to 1.0 and 3.2 mg/m{sup 3} H{sub 2}SO{sub 4} for 2 weeks, but exposure to H{sub 2}SO{sub 4} for 4 weeks did not show the enhancement of antigen-induced histamine release. A23187-induced histamine release was significantly enhanced by the exposure to 1.0 mg/m{sup 3} H{sub 2}SO{sub 4} or 4 ppm NO{sub 2} for 2 weeks, but suppression of histamine release from lung mast cells stimulated with A23187 was observed by the exposure to 3.2 mg/m{sup 3} H{sub 2}So{sub 4} for 4 weeks. The exposure to 0.3 mg/m{sup 3} H{sub 2}So{sub 4} showed no changes in antigen- and A23187-induced histamine release. The combination of 1.0 mg/m{sup 3} H{sub 2}So{sub 4} with 4 ppm NO{sub 2} for 2 weeks resulted in no changes in antigen- and A23187-induced histamine release. These results suggested that functional properties of lung mast cells may be altered by a low concentration of H{sub 2}So{sub 4} aerosol exposure.
- OSTI ID:
- 7159125
- Journal Information:
- Environmental Research; (United States), Vol. 58:1; ISSN 0013-9351
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
54 ENVIRONMENTAL SCIENCES
HISTAMINE
BIOCHEMICAL REACTION KINETICS
MAST CELLS
BIOLOGICAL FUNCTIONS
SULFURIC ACID
TOXICITY
AEROSOLS
GUINEA PIGS
INHALATION
NITROGEN DIOXIDE
AMINES
ANIMAL CELLS
ANIMALS
AZOLES
CHALCOGENIDES
COLLOIDS
CONNECTIVE TISSUE CELLS
DISPERSIONS
HETEROCYCLIC COMPOUNDS
HYDROGEN COMPOUNDS
IMIDAZOLES
INORGANIC ACIDS
INTAKE
KINETICS
MAMMALS
NITROGEN COMPOUNDS
NITROGEN OXIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXIDES
OXYGEN COMPOUNDS
REACTION KINETICS
RODENTS
SOLS
SOMATIC CELLS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology
540120 - Environment
Atmospheric- Chemicals Monitoring & Transport- (1990-)