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Title: Thallium kinetics in rat cardiac transplant rejection

Abstract

Cardiac transplant rejection is a very complex process involving both cellular and vascular injury. Recently, thallium imaging has been used to assess acute transplant rejection. It has been suggested that changes in thallium kinetics might be a sensitive indicator of transplant rejection. Accordingly, thallium kinetics were assessed in vivo in acute untreated rat heterotopic (cervical) transplant rejection. Male Lewis rats weighing 225-250 g received heterotopic heart transplants from syngeneic Lewis rats (group A; n = 13), or allogeneic Brown Norway rats (group B; n = 11). Rats were imaged serially on the 2nd and the 7th postoperative days. Serial cardiac thallium content was determined utilizing data collected every 150 sec for 2 hr. The data were fit to a monoexponential curve and the decay rate constant (/sec) derived. By day 7 all group B hearts had histological evidence of severe acute rejection, and demonstrated decreased global contraction. Group A hearts showed normal histology and contractility. However, thallium uptakes and washout of the two groups were the same. Peak thallium uptake of group B was +/- 3758 1166 counts compared with 3553 +/- 950 counts in the control group A (P = 0.6395); The 2-hr percentage of washout was 12.1 +/-more » 1.04 compared with 12.1 +/- 9.3 (P = 1.0000); and the decay constant was -0.00002065 +/- 0.00001799 compared with -0.00002202 +/- 0.00001508 (P = 0.8409). These data indicate that in vivo global thallium kinetics are preserved during mild-to-severe acute transplant rejection. These findings suggest that the complex cellular and extracellular processes of acute rejection limit the usefulness of thallium kinetics in the detection of acute transplant rejection.« less

Authors:
; ; ; ;
Publication Date:
Research Org.:
Massachusetts General Hospital, Boston (USA)
OSTI Identifier:
7154063
Resource Type:
Journal Article
Journal Name:
Transplantation; (United States)
Additional Journal Information:
Journal Volume: 45:4
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; HEART; RADIONUCLIDE KINETICS; TRANSPLANTS; THALLIUM ISOTOPES; UPTAKE; GRAFT-HOST REACTION; MYOCARDIUM; RADIOISOTOPE SCANNING; RATS; ANIMALS; BODY; CARDIOVASCULAR SYSTEM; COUNTING TECHNIQUES; ISOTOPES; MAMMALS; MUSCLES; ORGANS; RODENTS; VERTEBRATES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics; 560162 - Radionuclide Effects, Kinetics, & Toxicology- Animals, Plants, Microorganisms, & Cells

Citation Formats

Barak, J H, LaRaia, P J, Boucher, C A, Fallon, J T, and Buckley, M J. Thallium kinetics in rat cardiac transplant rejection. United States: N. p., 1988. Web. doi:10.1097/00007890-198804000-00004.
Barak, J H, LaRaia, P J, Boucher, C A, Fallon, J T, & Buckley, M J. Thallium kinetics in rat cardiac transplant rejection. United States. https://doi.org/10.1097/00007890-198804000-00004
Barak, J H, LaRaia, P J, Boucher, C A, Fallon, J T, and Buckley, M J. 1988. "Thallium kinetics in rat cardiac transplant rejection". United States. https://doi.org/10.1097/00007890-198804000-00004.
@article{osti_7154063,
title = {Thallium kinetics in rat cardiac transplant rejection},
author = {Barak, J H and LaRaia, P J and Boucher, C A and Fallon, J T and Buckley, M J},
abstractNote = {Cardiac transplant rejection is a very complex process involving both cellular and vascular injury. Recently, thallium imaging has been used to assess acute transplant rejection. It has been suggested that changes in thallium kinetics might be a sensitive indicator of transplant rejection. Accordingly, thallium kinetics were assessed in vivo in acute untreated rat heterotopic (cervical) transplant rejection. Male Lewis rats weighing 225-250 g received heterotopic heart transplants from syngeneic Lewis rats (group A; n = 13), or allogeneic Brown Norway rats (group B; n = 11). Rats were imaged serially on the 2nd and the 7th postoperative days. Serial cardiac thallium content was determined utilizing data collected every 150 sec for 2 hr. The data were fit to a monoexponential curve and the decay rate constant (/sec) derived. By day 7 all group B hearts had histological evidence of severe acute rejection, and demonstrated decreased global contraction. Group A hearts showed normal histology and contractility. However, thallium uptakes and washout of the two groups were the same. Peak thallium uptake of group B was +/- 3758 1166 counts compared with 3553 +/- 950 counts in the control group A (P = 0.6395); The 2-hr percentage of washout was 12.1 +/- 1.04 compared with 12.1 +/- 9.3 (P = 1.0000); and the decay constant was -0.00002065 +/- 0.00001799 compared with -0.00002202 +/- 0.00001508 (P = 0.8409). These data indicate that in vivo global thallium kinetics are preserved during mild-to-severe acute transplant rejection. These findings suggest that the complex cellular and extracellular processes of acute rejection limit the usefulness of thallium kinetics in the detection of acute transplant rejection.},
doi = {10.1097/00007890-198804000-00004},
url = {https://www.osti.gov/biblio/7154063}, journal = {Transplantation; (United States)},
number = ,
volume = 45:4,
place = {United States},
year = {Fri Apr 01 00:00:00 EST 1988},
month = {Fri Apr 01 00:00:00 EST 1988}
}