In vivo red cell destruction by anti-Lu6
- Duke Univ. Medical Center, Durham, NC (USA)
An example is presented of an IgG1, anti-Lu6, that reacted by indirect antiglobulin test and was capable of destroying antigen-positive red cells in vivo. Two methods for the measurement of red cell survival, {sup 51}Cr labeling and flow cytometry, gave the same result: 20 percent of the test dose of Lu:6 red cells was destroyed in the first hour after injection and 80 percent in the first 24 hours. The clinical relevance of the antibody was correctly predicted by an in vitro monocyte monolayer assay. The finding that this example of anti-Lu6 was clinically significant should not be taken to mean that all antibodies directed against high-incidence Lutheran and Lutheran system-related antigens will behave similarly. When such antibodies are encountered, in vivo and/or in vitro studies to assess their clinical significance are necessary before rare blood is used for transfusion.
- OSTI ID:
- 7137927
- Journal Information:
- Transfusion (Philadelphia); (USA), Vol. 30:3; ISSN 0041-1132
- Country of Publication:
- United States
- Language:
- English
Similar Records
Long-term in vivo survival of Rh(D)-negative donor red cells in a patient with anti-LW
Mechanisms of immune red cell destruction, and red cell compatibility testing
Related Subjects
BLOOD
TRANSFUSIONS
ERYTHROCYTES
SURVIVAL TIME
BLOOD GROUPS
CELL FLOW SYSTEMS
CHROMIUM 51
IMMUNOASSAY
IMMUNOGLOBULINS
MAN
TRACER TECHNIQUES
ANIMALS
BETA DECAY RADIOISOTOPES
BIOASSAY
BIOLOGICAL MATERIALS
BLOOD CELLS
BODY FLUIDS
CHROMIUM ISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
GLOBULINS
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MATERIALS
NUCLEI
ORGANIC COMPOUNDS
PRIMATES
PROTEINS
RADIOISOTOPES
THERAPY
VERTEBRATES
550201* - Biochemistry- Tracer Techniques