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Title: Positron emission tomography of fluorine-18-deoxyglucose and image-guided phosphorus-31 magnetic resonance spectroscopy in brain tumors

Abstract

Positron emission tomography (PET) of 2(18F)-fluoro-2-deoxy-D-glucose (FDG) and volume-selective phosphorus-31 magnetic resonance spectroscopy (31P-MRS) are methods used to assess the energy metabolism of the brain. Both methods were studied with respect to their contribution to differential diagnosis in 23 patients with various brain tumors. The various neuroectodermal tumors differed with respect to their metabolic rate for glucose (MRGL). Benign and malignant tumors could be better differentiated by using tumor metabolism relative to contralateral brain and by evaluating heterogeneities in tumors. Low-grade gliomas usually showed normal 31P-MR spectra; high-grade gliomas were characterized by reduced and often split phosphodiester peaks and alkaline pH. Meningiomas, which had variable MRGL, typically showed extremely low phosphocreatine levels, reduced phosphodiesters, and alkaline pH. We concluded that FDG-PET and 31P-MRS examine different aspects of tumor metabolism. Therefore, both can contribute independently and complementarily to the differential diagnosis of brain tumors.

Authors:
; ; ; ; ; ;  [1]
  1. Universitaet zu Koeln (Germany, F.R.)
Publication Date:
OSTI Identifier:
7137596
Resource Type:
Journal Article
Journal Name:
Journal of Nuclear Medicine; (USA)
Additional Journal Information:
Journal Volume: 31:3; Journal ID: ISSN 0161-5505
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BRAIN; IMAGE PROCESSING; GLIOMAS; DIAGNOSIS; GLUCOSE; METABOLISM; COMPARATIVE EVALUATIONS; FLUORINE 18; NMR IMAGING; PATIENTS; PHOSPHORUS 31; POSITRON COMPUTED TOMOGRAPHY; ALDEHYDES; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; CARBOHYDRATES; CENTRAL NERVOUS SYSTEM; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISEASES; EMISSION COMPUTED TOMOGRAPHY; FLUORINE ISOTOPES; HEXOSES; HOURS LIVING RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LIGHT NUCLEI; MONOSACCHARIDES; NEOPLASMS; NERVOUS SYSTEM; NUCLEI; ODD-EVEN NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANS; PHOSPHORUS ISOTOPES; PROCESSING; RADIOISOTOPES; SACCHARIDES; STABLE ISOTOPES; TOMOGRAPHY; 550601* - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Heiss, W D, Heindel, W, Herholz, K, Rudolf, J, Bunke, J, Jeske, J, and Friedmann, G. Positron emission tomography of fluorine-18-deoxyglucose and image-guided phosphorus-31 magnetic resonance spectroscopy in brain tumors. United States: N. p., 1990. Web.
Heiss, W D, Heindel, W, Herholz, K, Rudolf, J, Bunke, J, Jeske, J, & Friedmann, G. Positron emission tomography of fluorine-18-deoxyglucose and image-guided phosphorus-31 magnetic resonance spectroscopy in brain tumors. United States.
Heiss, W D, Heindel, W, Herholz, K, Rudolf, J, Bunke, J, Jeske, J, and Friedmann, G. 1990. "Positron emission tomography of fluorine-18-deoxyglucose and image-guided phosphorus-31 magnetic resonance spectroscopy in brain tumors". United States.
@article{osti_7137596,
title = {Positron emission tomography of fluorine-18-deoxyglucose and image-guided phosphorus-31 magnetic resonance spectroscopy in brain tumors},
author = {Heiss, W D and Heindel, W and Herholz, K and Rudolf, J and Bunke, J and Jeske, J and Friedmann, G},
abstractNote = {Positron emission tomography (PET) of 2(18F)-fluoro-2-deoxy-D-glucose (FDG) and volume-selective phosphorus-31 magnetic resonance spectroscopy (31P-MRS) are methods used to assess the energy metabolism of the brain. Both methods were studied with respect to their contribution to differential diagnosis in 23 patients with various brain tumors. The various neuroectodermal tumors differed with respect to their metabolic rate for glucose (MRGL). Benign and malignant tumors could be better differentiated by using tumor metabolism relative to contralateral brain and by evaluating heterogeneities in tumors. Low-grade gliomas usually showed normal 31P-MR spectra; high-grade gliomas were characterized by reduced and often split phosphodiester peaks and alkaline pH. Meningiomas, which had variable MRGL, typically showed extremely low phosphocreatine levels, reduced phosphodiesters, and alkaline pH. We concluded that FDG-PET and 31P-MRS examine different aspects of tumor metabolism. Therefore, both can contribute independently and complementarily to the differential diagnosis of brain tumors.},
doi = {},
url = {https://www.osti.gov/biblio/7137596}, journal = {Journal of Nuclear Medicine; (USA)},
issn = {0161-5505},
number = ,
volume = 31:3,
place = {United States},
year = {Thu Mar 01 00:00:00 EST 1990},
month = {Thu Mar 01 00:00:00 EST 1990}
}