Evaluation of body composition and nitrogen content of renal patients on chronic dialysis as determined by total body neutron activation
Total body protein (nitrogen), body cell mass (potassium), fat, and water were measured in 15 renal patients on maintenance hemodialysis (MHD). Total body nitrogen was measured by means of prompt ..gamma.. neutron activation analysis; total body water was determined with tritium labeled water; total body potassium was measured by whole body counting. The extracellular water was determined by a technique utilizing the measurement of total body chloride and plasma chloride. When compared with corresponding values of a control group of the same age, sex, and height, the protein content, body cell mass, and total body fat of the MHD patients were within the normal range. The only significant change was an increase in the extracellular water/body cell mass ratio in the male MHD patients compared to the control. The lack of significant difference of the nitrogen values of the MHD patients compared to matched controls suggests that dialysis minimizes any residual effects of uremic toxicity or protein-calorie malnutrition. These findings further suggest that there is a need to reevaluate the traditional anthropometric and biochemical standards of nutritional status for MHD patients. It was concluded that it is particularly important to measure protein stores of MHD patients with low protein intake to ascertain nutritional status. Finally, in vivo measurement of total body nitrogen and potassium for determination of body composition provides a simple, direct, and accurate assessment of the nutritional status of MHD patients.
- Research Organization:
- Brookhaven National Lab., Upton, NY
- DOE Contract Number:
- AC02-76CH00016
- OSTI ID:
- 7133812
- Journal Information:
- Am. J. Clin. Nutr.; (United States), Vol. 38
- Country of Publication:
- United States
- Language:
- English
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KIDNEYS
DIALYSIS
FAILURES
NITROGEN
ACTIVATION ANALYSIS
POTASSIUM
LABELLING
NUTRITION
PATIENTS
PROMPT NEUTRONS
PROTEINS
TRACER TECHNIQUES
TRITIUM
UREMIA
WHOLE-BODY COUNTING
ALKALI METALS
BARYONS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CHEMICAL ANALYSIS
COUNTING TECHNIQUES
ELEMENTARY PARTICLES
ELEMENTS
FERMIONS
FISSION NEUTRONS
HADRONS
HYDROGEN ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
METALS
NEUTRONS
NONMETALS
NUCLEI
NUCLEONS
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
SEPARATION PROCESSES
SYMPTOMS
YEARS LIVING RADIOISOTOPES
550901* - Pathology- Tracer Techniques