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Title: Contribution of polycyclic aromatic hydrocarbons to the carcinogenic impact of gasoline engine exhaust condensate evaluated by implantation into the lungs of rats

Abstract

An attempt was made to identify the substances chiefly responsible for the carcinogenicity of gasoline engine exhaust condensate. A carcinogen-specific bioassay was performed by a comparison of the carcinogenic effect of various fractions with that of a total sample of automobile exhaust condensate, tested in two or three different doses. The results were examined by Probit analysis. After implantation into the lungs of OM rats, the condensate emitted from a gasoline-driven automobile and the fraction of polycyclic aromatic compounds consisting of more than 3 rings induced lung carcinomas and sarcomas. The tumor incidence demonstrated a clear-cut dose-response relationship. The fraction of polycyclic aromatic hydrocarbons (PAH) consisting of more than 3 rings accounted for about 81% of the total carcinogenicity of automobile exhaust condensate. This fraction represented only 2.8% by weight of the condensate. The content of benzo(a)pyrene (CAS: 50-32-8; 0.483 mg/g condensate) accounted for 2.4% of the total carcinogenicity of automobile exhaust condensate. Regarding the minor effect of the PAH-free fraction (approximately equal to 87% by wt), no evidence of cocarcinogenic activity was observed, since the total condensate as well as the PAH fraction consisting of more than 3 rings applied proportionally caused about the same tumor incidence.

Authors:
; ; ; ;
Publication Date:
Research Org.:
Biochemical Institute for Environmental Carcinogens, Ahrensburg, Federal Republic of Germany
OSTI Identifier:
7132541
Resource Type:
Journal Article
Journal Name:
J. Natl. Cancer Inst.; (United States)
Additional Journal Information:
Journal Volume: 72:3
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; EXHAUST GASES; CARCINOGENESIS; POLYCYCLIC AROMATIC HYDROCARBONS; BENZOPYRENE; CARCINOGEN SCREENING; CARCINOMAS; LUNGS; RATS; SARCOMAS; ANIMALS; AROMATICS; BODY; CONDENSED AROMATICS; DISEASES; FLUIDS; GASEOUS WASTES; GASES; HYDROCARBONS; MAMMALS; NEOPLASMS; ORGANIC COMPOUNDS; ORGANS; PATHOGENESIS; RESPIRATORY SYSTEM; RODENTS; SCREENING; VERTEBRATES; WASTES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)

Citation Formats

Grimmer, G, Brune, H, Deutsch-Wenzel, R, Dettbarn, G, and Misfeld, J. Contribution of polycyclic aromatic hydrocarbons to the carcinogenic impact of gasoline engine exhaust condensate evaluated by implantation into the lungs of rats. United States: N. p., 1984. Web.
Grimmer, G, Brune, H, Deutsch-Wenzel, R, Dettbarn, G, & Misfeld, J. Contribution of polycyclic aromatic hydrocarbons to the carcinogenic impact of gasoline engine exhaust condensate evaluated by implantation into the lungs of rats. United States.
Grimmer, G, Brune, H, Deutsch-Wenzel, R, Dettbarn, G, and Misfeld, J. 1984. "Contribution of polycyclic aromatic hydrocarbons to the carcinogenic impact of gasoline engine exhaust condensate evaluated by implantation into the lungs of rats". United States.
@article{osti_7132541,
title = {Contribution of polycyclic aromatic hydrocarbons to the carcinogenic impact of gasoline engine exhaust condensate evaluated by implantation into the lungs of rats},
author = {Grimmer, G and Brune, H and Deutsch-Wenzel, R and Dettbarn, G and Misfeld, J},
abstractNote = {An attempt was made to identify the substances chiefly responsible for the carcinogenicity of gasoline engine exhaust condensate. A carcinogen-specific bioassay was performed by a comparison of the carcinogenic effect of various fractions with that of a total sample of automobile exhaust condensate, tested in two or three different doses. The results were examined by Probit analysis. After implantation into the lungs of OM rats, the condensate emitted from a gasoline-driven automobile and the fraction of polycyclic aromatic compounds consisting of more than 3 rings induced lung carcinomas and sarcomas. The tumor incidence demonstrated a clear-cut dose-response relationship. The fraction of polycyclic aromatic hydrocarbons (PAH) consisting of more than 3 rings accounted for about 81% of the total carcinogenicity of automobile exhaust condensate. This fraction represented only 2.8% by weight of the condensate. The content of benzo(a)pyrene (CAS: 50-32-8; 0.483 mg/g condensate) accounted for 2.4% of the total carcinogenicity of automobile exhaust condensate. Regarding the minor effect of the PAH-free fraction (approximately equal to 87% by wt), no evidence of cocarcinogenic activity was observed, since the total condensate as well as the PAH fraction consisting of more than 3 rings applied proportionally caused about the same tumor incidence.},
doi = {},
url = {https://www.osti.gov/biblio/7132541}, journal = {J. Natl. Cancer Inst.; (United States)},
number = ,
volume = 72:3,
place = {United States},
year = {Thu Mar 01 00:00:00 EST 1984},
month = {Thu Mar 01 00:00:00 EST 1984}
}