Ozone-induced tolerance to hyperoxia in rats

Journal Article · Thu Mar 01 00:00:00 EST 1984 · Am. Rev. Respir. Dis.; (United States)

OSTI ID:7132540

Jackson, R M; Frank, L

Preexposure of adult rats to ozone (0.8 +/- 0.1 ppm for 7 days) has been found to produce a marked degree of tolerance to hyperoxia (greater than 95% O2). The survival of O/sub 3/-preexposed rats in hyperoxia for 168 h was 28 of 32 (88%) compared with a rate of 2 of 18 (11%) for nonpreexposed rats. Total lung superoxide dismutase (SOD), glutathione peroxidase (GP), glucose 6-phosphate dehydrogenase (G6-PD), and catalase (CAT) activities were all significantly increased after O/sub 3/ preexposure and after the subsequent hyperoxic challenge. Probable mechanisms accounting for the markedly improved survival in hyperoxia after O/sub 3/ preexposure include both increased lung antioxidant enzyme and repair of structural damage by proliferation of alveolar lining cells. The demonstration of cross-tolerance between the atmospheric oxidants O/sub 3/ and O/sub 2/ suggests that there are similarities in the lung's adaptation to both oxidants.

• Research Organization: University of Miami School of Medicine, Pulmonary Division, Oak Asthma Research and Treatment Facility, Florida
• OSTI ID: 7132540
• Journal Information: Am. Rev. Respir. Dis.; (United States), Vol. 129:3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
OXYGEN
TOLERANCE
OZONE
BIOLOGICAL EFFECTS
CATALASE
ENZYME ACTIVITY
OXIDOREDUCTASES
PEROXIDASES
RATS
RESPIRATION
SUPEROXIDE DISMUTASE
ANIMALS
CARBOXYLIC ACIDS
ELEMENTS
ENZYMES
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
MAMMALS
NONMETALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PORPHYRINS
RODENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)