skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Effect of high fat, fiber and caloric restriction on rat mammary tumorigenesis

Abstract

Female rats given 7,12-Dimethylbenz(a)anthracene (DMBA) were placed on diets of control fat (CF-4.5%) or high fat (HF-20%) with either control fiber (6%) or high fiber (FB-12%). A 60% reduction in the CF diet was used to study the effects of caloric restriction on tumorigenesis. Results showed that HF diets had a shorter latency period than CF rats. The respective average number of tumors per rat and tumor volume were 7.3 +/- 1.3 and 23694 mm/sup 2/ for rats on a HF diet and 5.1+/-1.1 and 9144 mm/sup 3/ for CF rats. Addition of high fiber to the diets reduced the tumor incidence from 95% to 70% in the CF group but did not reduce the incidence in HF group. Although tumor number was reduced to 3.7+/-1.5 in CF+FB rats, the tumor volumes were not reduced (8950 mm/sup 3/). Rats fed HF+FB did not have fewer tumors (7.0+/-1.1), but did show a 53% reduction in tumor load. The estrogen dependent enzyme glucose-6-phosphate dehydrogenase was not affected by dietary levels of fat, which suggests that the promotional effects of fat may not be through estrogen stimulation. None of the caloric restricted rats had tumors 12 weeks post-DMBA. These restricted rats all hadmore » significantly elevated levels of serum corticosterone.« less

Authors:
; ;
Publication Date:
Research Org.:
Morehead State Univ., KY
OSTI Identifier:
7132261
Report Number(s):
CONF-8604222-
Journal ID: CODEN: FEPRA
Resource Type:
Journal Article
Journal Name:
Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
Additional Journal Information:
Journal Volume: 45:4; Conference: 70. annual meeting of the Federation of American Society for Experimental Biology, St. Louis, MO, USA, 13 Apr 1986
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; DIMETHYLBENZANTHRACENE; CARCINOGENESIS; FATS; BIOLOGICAL EFFECTS; FIBERS; MAMMARY GLANDS; NEOPLASMS; CORTICOSTERONE; DIET; OXIDOREDUCTASES; RATS; ADRENAL HORMONES; ANIMALS; AROMATICS; BODY; CONDENSED AROMATICS; CORTICOSTEROIDS; DISEASES; ENZYMES; GLANDS; GLUCOCORTICOIDS; HORMONES; HYDROXY COMPOUNDS; KETONES; MAMMALS; ORGANIC COMPOUNDS; ORGANS; PATHOGENESIS; PREGNANES; RODENTS; STEROID HORMONES; STEROIDS; VERTEBRATES; 560300* - Chemicals Metabolism & Toxicology; 550900 - Pathology

Citation Formats

Magrane, D, Van Sant, J, and Butler, B. Effect of high fat, fiber and caloric restriction on rat mammary tumorigenesis. United States: N. p., 1986. Web.
Magrane, D, Van Sant, J, & Butler, B. Effect of high fat, fiber and caloric restriction on rat mammary tumorigenesis. United States.
Magrane, D, Van Sant, J, and Butler, B. 1986. "Effect of high fat, fiber and caloric restriction on rat mammary tumorigenesis". United States.
@article{osti_7132261,
title = {Effect of high fat, fiber and caloric restriction on rat mammary tumorigenesis},
author = {Magrane, D and Van Sant, J and Butler, B},
abstractNote = {Female rats given 7,12-Dimethylbenz(a)anthracene (DMBA) were placed on diets of control fat (CF-4.5%) or high fat (HF-20%) with either control fiber (6%) or high fiber (FB-12%). A 60% reduction in the CF diet was used to study the effects of caloric restriction on tumorigenesis. Results showed that HF diets had a shorter latency period than CF rats. The respective average number of tumors per rat and tumor volume were 7.3 +/- 1.3 and 23694 mm/sup 2/ for rats on a HF diet and 5.1+/-1.1 and 9144 mm/sup 3/ for CF rats. Addition of high fiber to the diets reduced the tumor incidence from 95% to 70% in the CF group but did not reduce the incidence in HF group. Although tumor number was reduced to 3.7+/-1.5 in CF+FB rats, the tumor volumes were not reduced (8950 mm/sup 3/). Rats fed HF+FB did not have fewer tumors (7.0+/-1.1), but did show a 53% reduction in tumor load. The estrogen dependent enzyme glucose-6-phosphate dehydrogenase was not affected by dietary levels of fat, which suggests that the promotional effects of fat may not be through estrogen stimulation. None of the caloric restricted rats had tumors 12 weeks post-DMBA. These restricted rats all had significantly elevated levels of serum corticosterone.},
doi = {},
url = {https://www.osti.gov/biblio/7132261}, journal = {Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)},
number = ,
volume = 45:4,
place = {United States},
year = {Wed Mar 05 00:00:00 EST 1986},
month = {Wed Mar 05 00:00:00 EST 1986}
}