Monte-Carlo approach to the microdosimetry of /sup 224/Ra in murine compact and cancellous bone

Journal Article · Wed Jun 01 00:00:00 EDT 1988 · Health Phys.; (United States)

DOI:https://doi.org/10.1097/00004032-198806000-00002· OSTI ID:7125487

Humphreys, E R; Humm, J L

A method is described which allows dose calculations to be made to individual target cells in different regions of mouse bone marrow exposed to alpha particles emitted from bone. The method takes into account the variable rate of transfer of energy along the tracks of alpha particles and was applied to experiment-based values calculated for the concentration of /sup 224/Ra on bone surfaces after an injection of a leukemogenic amount of the nuclide. These calculations show a minimum dose of 11 Gy in small (less than 50-micron) marrow spaces and 10 Gy close to bone surface in the shaft of the femur. The results suggest that leukemogenic doses are likely to occur at some distance from bone surfaces in wide marrow spaces and that osteosarcoma is not likely to be induced directly in cells immediately aligning bone surfaces.

• Research Organization: MRC Radiobiology Unit, Chilton, Oxon (England)
• OSTI ID: 7125487
• Journal Information: Health Phys.; (United States), Vol. 54:6
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
OSTEOSARCOMAS
RADIOINDUCTION
RADIUM 224
MICRODOSIMETRY
SKELETON
RADIONUCLIDE KINETICS
ABSORPTION
ALPHA PARTICLES
BONE MARROW
MICE
MONTE CARLO METHOD
RADIATION MONITORING
RADIOACTIVITY
ALKALINE EARTH ISOTOPES
ALPHA DECAY RADIOISOTOPES
ANIMAL TISSUES
ANIMALS
BODY
CHARGED PARTICLES
DAYS LIVING RADIOISOTOPES
DISEASES
DOSIMETRY
EVEN-EVEN NUCLEI
HEAVY NUCLEI
HEMATOPOIETIC SYSTEM
ISOTOPES
MAMMALS
MONITORING
NEOPLASMS
NUCLEI
ORGANS
RADIOISOTOPES
RADIUM ISOTOPES
RODENTS
SARCOMAS
SKELETAL DISEASES
TISSUES
VERTEBRATES
560162* - Radionuclide Effects
Kinetics
& Toxicology- Animals
Plants
Microorganisms
& Cells