Effects of DDT on the calcium transport and thymidine uptake of bovine lymphocytes
It is known that organochlorine compounds in the environment present risks which may be related to an interference with calcium metabolism. The evidence in favor of a role for intracellular calcium levels as signals for the initiation of cell division is summarized by Metcalfe et al., and forms the basis for a calcium hypothesis for the control of cell growth. Lymphocytes undergoing transformation provide evidence for an involvement of calcium in the steps preceding mitogenic activation which occur within 20 hours of exposure to a mitogen. It has been suspected for some time that the incidence of lymphomas and leukemias may be higher in farming populations with significant past exposure to several organochlorine insecticides. It is also known that immune suppression can provoke an increase in the incidence of certain cancers, although whether this is an example of (lack of) immune surveillance for potential cancer cells or of some less direct mechanism such as a reduced resistance to a viral infection, is still unclear. For these reasons it is important to know whether DDT and other chemically related organochlorine compounds modulate calcium levels within lymphocytes, and if so whether this modulation relates to the observed effects of these compounds on lymphocyte mitogenesis. Such studies may also be of some value in providing a clue as to the relationship between chemically induced leukemias and DDT exposure.
- Research Organization:
- National Univ. of Singapore, Kent Ridge
- OSTI ID:
- 7117970
- Journal Information:
- Bull. Environ. Contam. Toxicol.; (United States), Vol. 37:4
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
CALCIUM 45
UPTAKE
DDT
BIOLOGICAL EFFECTS
TRITIUM COMPOUNDS
CALCIUM COMPOUNDS
CATTLE
LYMPHOCYTES
METABOLISM
THYMIDINE
ALKALINE EARTH ISOTOPES
ALKALINE EARTH METAL COMPOUNDS
ANIMAL CELLS
ANIMALS
AROMATICS
AZINES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CALCIUM ISOTOPES
CONNECTIVE TISSUE CELLS
DAYS LIVING RADIOISOTOPES
DOMESTIC ANIMALS
EVEN-ODD NUCLEI
HETEROCYCLIC COMPOUNDS
INSECTICIDES
INTERMEDIATE MASS NUCLEI
ISOTOPES
LABELLED COMPOUNDS
LEUKOCYTES
MAMMALS
MATERIALS
NUCLEI
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PESTICIDES
PYRIMIDINES
RADIOISOTOPES
RIBOSIDES
RUMINANTS
SOMATIC CELLS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology
550601 - Medicine- Unsealed Radionuclides in Diagnostics