Mercury in the dorsal root ganglia of rats treated with inorganic or organic mercury
- Univ. of Aarhus (Denmark)
Autometallographic silver amplification has been used to demonstrate the localization of mercury deposits in rat dorsal root ganglia after repeated intraperitoneal injections of mercuric chloride or methylmercuric chloride. The silver-enhanced mercury deposits were demonstrated with the light and electron microscope. The degree of intracellular staining of the individual cells depended on the mercury compound and total dosage. Ganglion cells (types A and B) and macrophages were found to accumulate mercury after a total dosage of 400 {mu}g HgCl{sub 2}. After 600 {mu}g HgCl{sub 2}, satellite cells, endothelial cells and fibroblasts were additionally found to contain mercury deposits. Treatment with 6,000 {mu}g CH{sub 3}HgCl caused faint staining of type A and B ganglion cells and fibroblasts. Macrophages, however, were the most heavily stained cells after treatment with CH{sub 3}HgCl. Ultrastructurally, mercury was exclusively located in lysosomes. This was irrespective of the cell type and mercury compound used for treatment.
- OSTI ID:
- 7111121
- Journal Information:
- Environmental Research; (United States), Vol. 56:1; ISSN 0013-9351
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
MERCURY COMPOUNDS
BIOLOGICAL LOCALIZATION
NERVE CELLS
SENSITIVITY
ORGANIC MERCURY COMPOUNDS
ENDOTHELIUM
FIBROBLASTS
INTRAPERITONEAL INJECTION
MACROPHAGES
MERCURY CHLORIDES
METABOLISM
RATS
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BODY
CHLORIDES
CHLORINE COMPOUNDS
CONNECTIVE TISSUE CELLS
HALIDES
HALOGEN COMPOUNDS
INJECTION
INTAKE
MAMMALS
MERCURY HALIDES
ORGANIC COMPOUNDS
PHAGOCYTES
RODENTS
SOMATIC CELLS
TISSUES
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology