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Title: Inhalation developmental toxicology studies: Teratology study of tetrahydrofuran in mice and rats: Final report

Tetrahydrofuran (THF), a four-carbon cyclic ether, is widely used as an industrial solvent. Although it has been used in large quantities for many years, few long-term toxicology studies, and no reproductive or developmental studies, have been conducted on THF. This study addresses the potential for THF to cause developmental toxicity in rodents by exposing Sprague-Dawley rats and Swiss (CD-1) mice to 0, 600, 1800, or 5000 ppm tetrahydrofuran (THF) vapors, 6 h/day, 7 dy/wk. Each treatment group consisted of 10 virgin females (for comparison), and approx.33 positively mated rats or mice. Positively mated mice were exposed on days 6--17 of gestation (dg), and rats on 6--19 dg. The day of plug or sperm detection was designated as O dg. Body weights were obtained throughout the study period, and uterine and fetal body weights were obtained at sacrifice (rats, 20 dg; mice, 18 dg). Implants were enumerated and their status recorded and live fetuses were examined for gross, visceral, skeletal, and soft-tissue craniofacial defects. 27 refs., 6 figs., 23 tabs.
Authors:
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Publication Date:
OSTI Identifier:
7090818
Report Number(s):
PNL-6685
ON: DE89001383
DOE Contract Number:
AC06-76RL01830
Resource Type:
Technical Report
Resource Relation:
Other Information: Portions of this document are illegible in microfiche products
Research Org:
Pacific Northwest Lab., Richland, WA (USA)
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; LITTER SIZE; COMPARATIVE EVALUATIONS; TETRAHYDROFURAN; TERATOGENESIS; VOLATILE MATTER; TOXICITY; CONGENITAL MALFORMATIONS; DOSE-RESPONSE RELATIONSHIPS; FETUSES; INHALATION; LIFE SPAN; MICE; MORTALITY; PRENATAL EXPOSURE; PROGRESS REPORT; RATS; SEX DEPENDENCE; TIME DEPENDENCE; ANIMALS; DOCUMENT TYPES; FURANS; HETEROCYCLIC COMPOUNDS; INTAKE; MALFORMATIONS; MAMMALS; MATTER; ORGANIC COMPOUNDS; ORGANIC OXYGEN COMPOUNDS; PATHOLOGICAL CHANGES; RODENTS; VERTEBRATES 560300* -- Chemicals Metabolism & Toxicology