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Title: Total body nitrogen in health and disease: effects of age, weight, height, and sex

Total body levels of nitrogen were measured by prompt-gamma neutron activation analysis in 136 healthy adults in the general population (age 20 to 80 years), in 55 cancer patients, and in 20 obese subjects. In order to evaluate the TBN values for the patients, it was necessary to normalize the data for possible differences due to body habitus. This normalization was defined as the ratio of the measured nitrogen level to a predicted nitrogen level derived from the normal population. The parameters of sex, age, height, weight, and fat were used to calculate expected normal values of nitrogen. For the cancer patients, an average TBN deficit of less than 10% was observed. Individual patients, however, showed deviations from the TBN/sub p/ value as large as 28%. For obese patients, the TBN values were normal to slightly high. When adjusted for body size, the deficit of TBN in the cancer patients was approximately half that observd for TBK.
Authors:
; ; ; ;
Publication Date:
OSTI Identifier:
7089664
Resource Type:
Journal Article
Resource Relation:
Journal Name: J. Lab. Clin. Med.; (United States); Journal Volume: 99:6
Research Org:
Brookhaven National Lab., Upton, NY
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; NITROGEN; METABOLISM; ACTIVATION ANALYSIS; ADIPOSE TISSUE; AGE DEPENDENCE; CALCIUM; GAMMA RADIATION; HEIGHT; HUMAN POPULATIONS; IN VIVO; METABOLIC DISEASES; NEOPLASMS; NEUTRON REACTIONS; PATIENTS; POTASSIUM; QUANTITY RATIO; SEX DEPENDENCE; WEIGHT; ALKALI METALS; ALKALINE EARTH METALS; ANIMAL TISSUES; BARYON REACTIONS; BODY; CHEMICAL ANALYSIS; CONNECTIVE TISSUE; DIMENSIONS; DISEASES; ELECTROMAGNETIC RADIATION; ELEMENTS; HADRON REACTIONS; IONIZING RADIATIONS; METALS; NONMETALS; NUCLEAR REACTIONS; NUCLEON REACTIONS; POPULATIONS; RADIATIONS; TISSUES 550500* -- Metabolism