Secretin enhances (/sup 14/C)erythritol clearance in unanesthetized dogs

Journal Article · Fri Jan 01 00:00:00 EST 1982 · Dig. Dis. Sci.; (United States)

DOI:https://doi.org/10.1007/BF01308122· OSTI ID:7086612

Lewis, M H; Baker, A L; Dhorajiwala, J; Moossa, A R

To determine the effect of secretin infusion on clearance of inert markers into bile, unanesthetized dogs fitted with Thomas cannulas received continuous infusions of (/sup 14/C)erythritol and (/sup 3/H)inulin throughout study. Taurocholic acid administered sequentially at 9.0, 20.0, and 40.0 mumol/min enhanced (/sup 14/C)erythritol clearance, and GIH secretin (3 units/min) administered along with TCA (40.0 mumol/min) increased (/sup 14/C)erythritol clearance from 4.9 +/- 1.2 ml/10 min to 6.8 +/- 1.3 ml/10 min (P less than 0.001), but simultaneously measured (/sup 3/H)inulin clearance was unaltered. Secretin alone also increased (/sup 14/C)erythritol clearance but did not alter (/sup 3/H)inulin clearance. The increase in (/sup 14/C)erythritol clearance per unit increase in bile flow was less during secretin infusion than TCA. Thus, secretin increases (/sup 14/C)erythritol transport through restricted channels, probably distal to the canaliculi. (/sup 14/C)Erythritol may not be an accurate marker for canalicular bile flow in dogs during secretin infusion.

• Research Organization: Department of Medicine, The University of Chicago, IL
• OSTI ID: 7086612
• Journal Information: Dig. Dis. Sci.; (United States), Vol. 27:1
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
BILE
CLEARANCE
CARBON 14 COMPOUNDS
ISOTOPE APPLICATIONS
TRANSLOCATION
MEASURING METHODS
TRITIUM COMPOUNDS
BILIARY TRACT
COMPARATIVE EVALUATIONS
DOGS
ERYTHRITOL
PHYSIOLOGY
QUANTITY RATIO
SECRETIN
TRACER TECHNIQUES
ALCOHOLS
ANIMALS
BIOLOGICAL MATERIALS
BODY FLUIDS
CARBOHYDRATES
DIGESTIVE SYSTEM
HORMONES
HYDROXY COMPOUNDS
LABELLED COMPOUNDS
MAMMALS
MATERIALS
MONOSACCHARIDES
ORGANIC COMPOUNDS
SACCHARIDES
VERTEBRATES
551001* - Physiological Systems- Tracer Techniques
400702 - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials
550201 - Biochemistry- Tracer Techniques