Antihypertensive effect of eicosapentaenoic acid (EPA) on spontaneously hypertensive rats (SHR)

Conference · Wed Mar 05 00:00:00 EST 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)

OSTI ID:7085864

Lam, B K; Quilley, J; Hirai, A; Yoshida, S; Tamura, Y; Wong, P Y.K.

EPA ethyl ester (99.8% pure) was administered orally (300 mg/kg/d) to adult (25-wk-old) and young (11 1/2-wk-old) SHR rats for 2 weeks at which time systolic blood pressure (BP), platelet aggregation, glomerular leukotriene (LT)A/sub 4/ hydrolase activity, plasma renin activity (PRA), urinary levels of TxB/sub 2/ and 6-keto-PGF/sub 1..cap alpha../ and aortic conversion of (/sup 14/C)-AA to (/sup 14/C)-6-keto-PGF/sub 1..cap alpha../ were measured. EPA treatment decreased BP of adult SHR with established hypertension from 238.7 +/- 2 to 217 +/- 4 mmHg (M +/- SD, P < 0.001) and retarded the development of hypertension in young SHR rats (178 +/- 6 vs. 218 +/- 4 mmHg in controls, p < 0.001). Platelets showed decreased responsiveness to ADP (3 ..mu..M) and glomerular LTA/sub 4/ hydrolase activity was inhibited. PRA and urinary levels of TxB/sub 2/ and 6-keto-PGF/sub 1..cap alpha../ were not changed. Similarly, there was no change in aortic conversion of (/sup 14/C)-AA to (/sup 14/C)-6-keto-PGF/sub 1..cap alpha../ indicating that EPA treatment does not alter vascular cyclo-oxygenase activity. These results indicate that EPA treatment affects eicosanoid metabolism and cardiovascular function.

• Research Organization: New York Medical College, Valhalla
• OSTI ID: 7085864
• Report Number(s): CONF-8604222-; TRN: 87-008955
• Journal Information: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Vol. 45:4; Conference: 70. annual meeting of the Federation of American Society for Experimental Biology, St. Louis, MO, USA, 13 Apr 1986
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
EICOSANOIC ACID
METABOLISM
HYDROLASES
ENZYME ACTIVITY
HYPERTENSION
PATHOGENESIS
ARACHIDONIC ACID
BLOOD COAGULATION
BLOOD PRESSURE
CARBON 14 COMPOUNDS
RATS
TRACER TECHNIQUES
ANIMALS
CARBOXYLIC ACIDS
CARDIOVASCULAR DISEASES
DISEASES
ENZYMES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MONOCARBOXYLIC ACIDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
RODENTS
SYMPTOMS
VASCULAR DISEASES
VERTEBRATES
550901* - Pathology- Tracer Techniques