skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Vascular tracers alter hemodynamics and airway pressure in anesthetized sheep

Abstract

The technique of vascular labeling was developed to mark sites of increased microvascular permeability. We used the vascular labeling technique in anesthetized sheep and found that hemodynamics and airway pressure were adversely affected by intraarterial infusions of two vascular tracers. Monastral blue (nine sheep) immediately caused systemic arterial hypotension, pulmonary arterial hypertension, and bronchoconstriction. All three physiological responses were partially blocked by a cyclooxygenase inhibitor (indomethacin) but not by an H1-antihistamine (chlorpheniramine). Colloidal gold (nine sheep) caused immediate, but less dramatic, pulmonary arterial hypertension which was not attenuated by the blocking agents. We conclude that these two vascular tracers caused detrimental physiological side effects in sheep at the usual doses used to label injured microvessels in other species.

Authors:
;
Publication Date:
Research Org.:
Univ. of South Florida, Tampa
OSTI Identifier:
7082249
Resource Type:
Journal Article
Journal Name:
Microvasc. Res.; (United States)
Additional Journal Information:
Journal Volume: 3
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BLOOD VESSELS; PERMEABILITY; GOLD ISOTOPES; SIDE EFFECTS; RADIOPHARMACEUTICALS; BLOOD PRESSURE; ENZYME INHIBITORS; HYPERTENSION; INDOLES; SHEEP; VASOCONSTRICTION; ANIMALS; AROMATICS; AZAARENES; AZOLES; BODY; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; DISEASES; DOMESTIC ANIMALS; DRUGS; HETEROCYCLIC COMPOUNDS; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PYRROLES; RUMINANTS; SYMPTOMS; VASCULAR DISEASES; VERTEBRATES; 560162* - Radionuclide Effects, Kinetics, & Toxicology- Animals, Plants, Microorganisms, & Cells

Citation Formats

Albertine, K H, and Staub, N C. Vascular tracers alter hemodynamics and airway pressure in anesthetized sheep. United States: N. p., 1986. Web. doi:10.1016/0026-2862(86)90065-8.
Albertine, K H, & Staub, N C. Vascular tracers alter hemodynamics and airway pressure in anesthetized sheep. United States. https://doi.org/10.1016/0026-2862(86)90065-8
Albertine, K H, and Staub, N C. 1986. "Vascular tracers alter hemodynamics and airway pressure in anesthetized sheep". United States. https://doi.org/10.1016/0026-2862(86)90065-8.
@article{osti_7082249,
title = {Vascular tracers alter hemodynamics and airway pressure in anesthetized sheep},
author = {Albertine, K H and Staub, N C},
abstractNote = {The technique of vascular labeling was developed to mark sites of increased microvascular permeability. We used the vascular labeling technique in anesthetized sheep and found that hemodynamics and airway pressure were adversely affected by intraarterial infusions of two vascular tracers. Monastral blue (nine sheep) immediately caused systemic arterial hypotension, pulmonary arterial hypertension, and bronchoconstriction. All three physiological responses were partially blocked by a cyclooxygenase inhibitor (indomethacin) but not by an H1-antihistamine (chlorpheniramine). Colloidal gold (nine sheep) caused immediate, but less dramatic, pulmonary arterial hypertension which was not attenuated by the blocking agents. We conclude that these two vascular tracers caused detrimental physiological side effects in sheep at the usual doses used to label injured microvessels in other species.},
doi = {10.1016/0026-2862(86)90065-8},
url = {https://www.osti.gov/biblio/7082249}, journal = {Microvasc. Res.; (United States)},
number = ,
volume = 3,
place = {United States},
year = {Sat Nov 01 00:00:00 EST 1986},
month = {Sat Nov 01 00:00:00 EST 1986}
}