Multicomponent redox catalysts for reduction of large biological molecules using molecular hydrogen as the reductant
One-electron reduction of the large biological molecules horse heart cytochrome c, sperm whale myoglobin, and horseradish peroxidase using H/sub 2/ as the reductant can be catalyzed by two-component, high surface area heterogeneous catalysts. The catalysts can be prepared by first functionalizing high surface area SiO/sub 2/ with a polycationic polymer into which is dispersed MCl/sub 4//sup 2 -/ (M = Pd, Pt). Reduction with H/sub 2/ yields elemental Pd or Pt dispersed in the polymer. The particles are finally functionalized with a redox polymer derived from hydrolysis of Si(OR)/sub 3/ groups of an N,N'-dialkyl-4,4'-bipyridinium- or from a cobalticenium-based monomer. The two components of the heterogeneous catalysts are the buried noble metal capable of activating the H/sub 2/ and the redox polymer, which can equilibrate both with the noble metal and with the large biological molecule. Reduction of the large biological molecules in aqueous solution can be effected at room temperature and 1 atm H/sub 2/ using the catalysts under conditions where the biological materials would not be reducible with H/sub 2/ alone or when the noble metal alone would be used as the catalyst.
- Research Organization:
- Massachusetts Institute of Technology, Cambridge (USA)
- OSTI ID:
- 7076825
- Journal Information:
- J. Am. Chem. Soc.; (United States), Vol. 110:7
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
CYTOCHROMES
REDUCTION
PALLADIUM
CATALYTIC EFFECTS
PEROXIDASES
PLATINUM
AQUEOUS SOLUTIONS
CATALYSIS
CATALYSTS
EXPERIMENTAL DATA
HYDROGEN
MEDIUM TEMPERATURE
REDOX REACTIONS
SURFACE AREA
CHEMICAL REACTIONS
DATA
DISPERSIONS
ELEMENTS
ENZYMES
INFORMATION
METALS
MIXTURES
NONMETALS
NUMERICAL DATA
ORGANIC COMPOUNDS
OXIDOREDUCTASES
PIGMENTS
PLATINUM METALS
PROTEINS
SOLUTIONS
SURFACE PROPERTIES
TRANSITION ELEMENTS
400201* - Chemical & Physicochemical Properties