Characteristics and specificity of acquired immunologic memory to Mycobacterium tuberculosis infection

Journal Article · Sun May 15 00:00:00 EDT 1988 · J. Immunol.; (United States)

OSTI ID:7067795

Orme, I M

The results herein show that mice infected with Mycobacterium tuberculosis and then exposed to a protracted course of isoniazid chemotherapy possess a heightened state of acquired resistance to subsequent challenge with the homologous organism. Our results provide the first evidence, moreover, that this resistance is mediated by a long-lived, cyclophosphamide- and irradiation-resistant L3T4+ Lyt-2- lymphocyte capable of giving rise to an accelerated re-emergence of resistance in the animal upon rechallenge. Evidence is also provided to show that triggering of this memory-immune T cell population in the re-challenged host was associated with the rapid emergence of non-specific resistance to secondary bacterial infection; however, the accelerated emergence of this population was only observed if the challenge inoculum consisted of the living organism. The relevance of this latter finding to strategies for vaccine development is discussed.

• Research Organization: Colorado State Univ., Fort Collins (USA)
• OSTI ID: 7067795
• Journal Information: J. Immunol.; (United States), Vol. 140:10
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
LYMPHOCYTES
RADIOSENSITIVITY
MICE
IMMUNITY
MYCOBACTERIUM TUBERCULOSIS
INFECTIVITY
ISONIAZID
PHENOTYPE
TUBERCULOSIS
ANIMAL CELLS
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIMICROBIAL AGENTS
BACTERIA
BACTERIAL DISEASES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DISEASES
DRUGS
HYDRAZIDES
INFECTIOUS DISEASES
LEUKOCYTES
MAMMALS
MATERIALS
MICROORGANISMS
MYCOBACTERIUM
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RODENTS
SOMATIC CELLS
VERTEBRATES
553003* - Agriculture & Food Technology- Pest & Disease Control- (1987-)