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Title: Induction of chromosomal aberrations in bone marrow cells of asbestotic rats

In the present study, cytogenetic effects of Indian chrysotile asbestos in rat bone marrow cells after 290 days of intratracheal inoculation, when it develops massive pulmonary fibrosis, were investigated. The pulmonary fibrosis was confirmed by both histopathological studies and increased collagen content in the lung of the treated animals. In the asbestotic rats a significant increase in chromosomal aberrations was recorded and a decrease in mitotic index of bone marrow cells. The types of chromosomal aberrations in these cells were chromatid gaps and breaks. The results indicate the significant cytogenetic changes in the bone marrow cells of asbestotic rats and also suggest that these changes directly or indirectly may be one of the biological events involved in eliciting the asbestos-mediated toxic responses.
Authors:
; ; ;  [1]
  1. (Industrial Toxicology Research Centre, Lucknow (India))
Publication Date:
OSTI Identifier:
7066319
Resource Type:
Journal Article
Resource Relation:
Journal Name: Environmental Research; (United States); Journal Volume: 57:2
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ASBESTOS; GENETIC EFFECTS; BONE MARROW CELLS; CHROMOSOMAL ABERRATIONS; LUNGS; FIBROSIS; COLLAGEN; MITOTIC INDEX; RATS; ANIMAL CELLS; ANIMALS; BIOLOGICAL EFFECTS; BODY; CONNECTIVE TISSUE CELLS; MAMMALS; MUTATIONS; ORGANIC COMPOUNDS; ORGANS; PATHOLOGICAL CHANGES; PROTEINS; RESPIRATORY SYSTEM; RODENTS; SCLEROPROTEINS; SOMATIC CELLS; VERTEBRATES 560300* -- Chemicals Metabolism & Toxicology