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Title: Metronidazole in the treatment of cervical cancer using Cf-252 neutron brachytherapy

Metronidazole was tested for its possible use in the Cf-252 brachytherapy of cervical cancer as a radiosensitizer and to deal with anaerobic pelvic infection. 15 patients were treated by only 14 were evaluable. All stages from stage IB-IVB were treated and complete local tumor regression was noted in all cases although it could take place very slowly. 5/14 (36%) are 1.5-3 year survivors but only among the patients with stage I-II disease. No unusual radio-enhancing action was observed but metronidazole appeared to be useful to treat the vaginal, cervix and uterine infections often associated with high stage disease and bulky, ulcerative or necrotic tumors.
Authors:
Publication Date:
OSTI Identifier:
7063803
Resource Type:
Journal Article
Resource Relation:
Journal Name: Nucl. Sci. Appl.; (United States); Journal Volume: 2:3
Research Org:
Dept. of Radiation Medicine, Radiation Therapy Oncology Center, Univ. of Kentucky Medical Center, Lexington, KY 40536
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CALIFORNIUM 252; THERAPEUTIC USES; METRONIDAZOLE; NEOPLASMS; NEUTRON THERAPY; UTERUS; ANAEROBIC CONDITIONS; INFECTIVITY; NECROSIS; PATIENTS; PELVIS; RADIOSENSITIZERS; SURVIVAL TIME; ULCERS; ACTINIDE ISOTOPES; ACTINIDE NUCLEI; ALCOHOLS; ALPHA DECAY RADIOISOTOPES; ANTINEOPLASTIC DRUGS; AZOLES; BODY; BODY AREAS; CALIFORNIUM ISOTOPES; DISEASES; DRUGS; EVEN-EVEN NUCLEI; FEMALE GENITALS; HEAVY NUCLEI; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; IMIDAZOLES; ISOTOPES; MEDICINE; NITRO COMPOUNDS; NUCLEAR MEDICINE; NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PATHOLOGICAL CHANGES; RADIOISOTOPES; RADIOLOGY; RADIOTHERAPY; THERAPY; USES; YEARS LIVING RADIOISOTOPES 550603* -- Medicine-- External Radiation in Therapy-- (1980-); 550604 -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)