Predictive models for deposition of inhaled diesel exhaust particles in humans and laboratory species. Research report, July 1984-January 1987
A deposition model for diesel-exhaust particles was formulated mathematically from available scientific data, and was used to predict the deposition of particles in the airways of laboratory animals and of humans of different ages. In addition, a lung-growth model was formulated for humans, from infancy to adulthood, to predict the effect of age on deposition. The investigators predicted from their models that: (1) deposition in the alveoli is markedly affected by changes in the size distribution of particles; (2) nose- versus mouth-breathing had little effect on deposition in the alveoli; (3) increased minute ventilation substantially increased the rate of particle deposition; and (4) age (in humans) influenced the levels of deposition observed in the unciliated regions of the airways (the highest levels of deposition occurred in infants under two years, decreased in children over two years, and decreased again in adults aged 25 years or older); and (5) the deposition rate in laboratory animals was higher than in humans of all ages.
- Research Organization:
- Health Effects Inst., Cambridge, MA (USA)
- OSTI ID:
- 7052778
- Report Number(s):
- PB-88-234414/XAB; HEI/RR-87/19
- Resource Relation:
- Other Information: See also PB--88-234406
- Country of Publication:
- United States
- Language:
- English
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54 ENVIRONMENTAL SCIENCES
33 ADVANCED PROPULSION SYSTEMS
DIESEL ENGINES
EXHAUST GASES
PARTICULATES
INHALATION
AIR POLLUTION
DIFFUSION
LABORATORY ANIMALS
MATHEMATICAL MODELS
PARTICLE SIZE
PROGRESS REPORT
RESPIRATION
DOCUMENT TYPES
ENGINES
FLUIDS
GASEOUS WASTES
GASES
HEAT ENGINES
INTAKE
INTERNAL COMBUSTION ENGINES
PARTICLES
POLLUTION
SIZE
WASTES
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330705 - Emission Control- Particulates