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Title: Cadmium stimulates osteoclast-like multinucleated cell formation in mouse bone marrow cell cultures

Most of cadmium (Cd)-treated animals have been reported to show osteoporosis-like changes in bones. This suggests that Cd may promote bone loss by a direct action on bone. It was found that Cd stimulated prostaglandin E{sub 2}(PGE{sub 2}) production in the osteoblast-like cell, MC3T3-E1. Therefore, Cd stimulates bone resorption by increasing PGE{sub 2} production. Recently, several bone marrow cell culture systems have been developed for examining the formation of osteoclast-like multinucleated cells in vitro. As osteoblasts produce PGE{sub 2} by Cd-induced cyclooxygenase and may play an important role in osteoclast formation, the present study was undertaken to clarify the possibility that Cd might stimulate osteoclast formation in a mouse bone marrow culture system.
Authors:
; ; ; ; ; ;  [1]
  1. (Toyama Medical and Pharmaceutical Univ. (Japan))
Publication Date:
OSTI Identifier:
7050072
Resource Type:
Journal Article
Resource Relation:
Journal Name: Bulletin of Environmental Contamination and Toxicology; (United States); Journal Volume: 47:2
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BONE MARROW CELLS; ETIOLOGY; CADMIUM COMPOUNDS; BIOLOGICAL EFFECTS; OSTEOPOROSIS; CELL PROLIFERATION; METABOLISM; PROSTAGLANDINS; ANIMAL CELLS; CONNECTIVE TISSUE CELLS; DISEASES; SKELETAL DISEASES; SOMATIC CELLS 560300* -- Chemicals Metabolism & Toxicology