Does the genetic type of collagen determine fibril structure

Journal Article · Wed Oct 01 00:00:00 EDT 1980 · Biophys. J.; (United States)

DOI:https://doi.org/10.1016/S0006-3495(80)84939-3· OSTI ID:7032775

Eikenberry, E; Brodsky, B; Cassidy, K

A number of genetic types of collagen, all triple-helical but with significant variations in their amino acid sequences, have been found and the distribution of these genetic types is tissue specific. For example, tendon is composed only of type I collagen, while cartilage contains largely type II collagen. Skin contains a large amount of type I, but has a significant fraction, approx. 15%, of type III. Each of these types can form fibrils, but it is not known whether they form distinctive fibril structures that are important in determining tissue organization. We are using x-ray diffraction to analyze a variety of tissues with different collagen genetic types to compare the fibril structures and thus investigate whether genetic type is an important determinant of this structure.

• Research Organization: Rutgers Medical School, Piscataway, NJ
• OSTI ID: 7032775
• Journal Information: Biophys. J.; (United States), Vol. 32:1
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
COLLAGEN
STRUCTURAL CHEMICAL ANALYSIS
MOLECULAR STRUCTURE
GENETIC VARIABILITY
CONNECTIVE TISSUE
FIBERS
FOURIER TRANSFORMATION
GENETIC EFFECTS
MOLECULAR BIOLOGY
X-RAY DIFFRACTION
ANIMAL TISSUES
BIOLOGICAL EFFECTS
BIOLOGICAL VARIABILITY
BODY
COHERENT SCATTERING
DIFFRACTION
INTEGRAL TRANSFORMATIONS
ORGANIC COMPOUNDS
PROTEINS
SCATTERING
SCLEROPROTEINS
TISSUES
TRANSFORMATIONS
550200* - Biochemistry
551000 - Physiological Systems