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Title: Increased atrial natriuretic peptide (6-33) binding sites in the subfornical organ of water deprived and Brattleboro rats

Abstract

Binding sites for rat atrial natriuretic eptide (6-33) (ANP) were quantitated in the subfornical organ of chronically dehydrated homozygous Brattleboro rats unable to synthesize vasopressin; heterozygous Brattleboro rats, their controls, Long Evans rats and Long Evans rats after 4 days of water deprivation. Brain sections were incubated in the presence of /sup 125/I-ANP and the results analyzed by autoradiography coupled to computerized microdensitometry and comparison to /sup 125/I-standards. Brattleboro rats and water deprived Long Evans rats presented a higher number of ANP binding sites than their normally hydrated controls. The results suggest a role of ANP binding sites in the subfornical organ in the central regulation of fluid balance and vasopressin secretion.

Authors:
; ; ;
Publication Date:
Research Org.:
National Institute of Mental Health, Bethesda, MD
OSTI Identifier:
7025455
Resource Type:
Journal Article
Journal Name:
Proc. Soc. Exp. Biol. Med.; (United States)
Additional Journal Information:
Journal Volume: 182:4
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; BRAIN; AUTORADIOGRAPHY; PEPTIDES; BIOCHEMICAL REACTION KINETICS; DEHYDRATION; HOMEOSTASIS; IODINE 125; RATS; VASOPRESSIN; WATER; ANIMALS; BETA DECAY RADIOISOTOPES; BODY; CENTRAL NERVOUS SYSTEM; DAYS LIVING RADIOISOTOPES; ELECTRON CAPTURE RADIOISOTOPES; HORMONES; HYDROGEN COMPOUNDS; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; KINETICS; MAMMALS; NERVOUS SYSTEM; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; OXYGEN COMPOUNDS; PEPTIDE HORMONES; PITUITARY HORMONES; PROTEINS; RADIOISOTOPES; REACTION KINETICS; RODENTS; VERTEBRATES; 550201* - Biochemistry- Tracer Techniques

Citation Formats

Saavedra, J M, Israel, A, Correa, F M.A., and Kurihara, M. Increased atrial natriuretic peptide (6-33) binding sites in the subfornical organ of water deprived and Brattleboro rats. United States: N. p., 1986. Web. doi:10.3181/00379727-182-4-RC1.
Saavedra, J M, Israel, A, Correa, F M.A., & Kurihara, M. Increased atrial natriuretic peptide (6-33) binding sites in the subfornical organ of water deprived and Brattleboro rats. United States. https://doi.org/10.3181/00379727-182-4-RC1
Saavedra, J M, Israel, A, Correa, F M.A., and Kurihara, M. 1986. "Increased atrial natriuretic peptide (6-33) binding sites in the subfornical organ of water deprived and Brattleboro rats". United States. https://doi.org/10.3181/00379727-182-4-RC1.
@article{osti_7025455,
title = {Increased atrial natriuretic peptide (6-33) binding sites in the subfornical organ of water deprived and Brattleboro rats},
author = {Saavedra, J M and Israel, A and Correa, F M.A. and Kurihara, M},
abstractNote = {Binding sites for rat atrial natriuretic eptide (6-33) (ANP) were quantitated in the subfornical organ of chronically dehydrated homozygous Brattleboro rats unable to synthesize vasopressin; heterozygous Brattleboro rats, their controls, Long Evans rats and Long Evans rats after 4 days of water deprivation. Brain sections were incubated in the presence of /sup 125/I-ANP and the results analyzed by autoradiography coupled to computerized microdensitometry and comparison to /sup 125/I-standards. Brattleboro rats and water deprived Long Evans rats presented a higher number of ANP binding sites than their normally hydrated controls. The results suggest a role of ANP binding sites in the subfornical organ in the central regulation of fluid balance and vasopressin secretion.},
doi = {10.3181/00379727-182-4-RC1},
url = {https://www.osti.gov/biblio/7025455}, journal = {Proc. Soc. Exp. Biol. Med.; (United States)},
number = ,
volume = 182:4,
place = {United States},
year = {Mon Sep 01 00:00:00 EDT 1986},
month = {Mon Sep 01 00:00:00 EDT 1986}
}