Mechanisms of hypertension in renal radiation

Juncos, L; Cornejo, J C; Cejas, H; Broglia, C

doi:10.1161/01.HYP.15.2_Suppl.I132

Title: Mechanisms of hypertension in renal radiation

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Abstract

This study was undertaken to investigate the role played by renal functional and structural changes in the development of radiation-induced hypertension. Four groups of rats were studied: (1) left kidney radiated, (2) sham procedure, (3) uninephrectomy followed 3 weeks later by radiation of the contralateral kidney, and (4) uninephrectomy followed by sham procedure 3 weeks later. All radiated rats became hypertensive at 12 weeks (p less than 0.05) and had higher protein excretion (p less than 0.05). In the presence of an intact contralateral kidney, radiation causes mild-to-moderate histological abnormalities, and therefore, creatinine clearance and water and sodium handling do not change. Plasma renin activity increased in this group (p less than 0.05). Radiated uninephrectomized rats showed decreased creatinine clearance (p less than 0.05), but renin activity remained unchanged. These rats developed severe histological abnormalities in glomeruli, interstitia, tubuli, and vessels resulting in increased sodium and water output. The average of individual tubular and interstitial scores correlated significantly with both water intake and output but not with sodium excretion. These studies suggest that in the presence of an intact kidney, renin is an important determinant in the development or maintenance of radiation hypertension, whereas in the absence of the contralateralmore »« less

Authors:

Juncos, L; Cornejo, J C; Cejas, H; Broglia, C ^[1]

Instituto Privado de Especialidades Medicas, Cordoba (Argentina)

Publication Date:: Thu Feb 01 00:00:00 EST 1990

OSTI Identifier:: 7025195

Resource Type:: Journal Article

Journal Name:: Hypertension (Dallas); (USA)

Additional Journal Information:: Journal Volume: 15:2 Suppl; Journal ID: ISSN 0194-911X

Country of Publication:: United States

Language:: English

Subject:: 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; HYPERTENSION; RADIOINDUCTION; KIDNEYS; BIOLOGICAL RADIATION EFFECTS; BLOOD PRESSURE; CREATININE; MORPHOLOGICAL CHANGES; NEPHRECTOMY; RADIATION INJURIES; RATS; ANIMALS; AZOLES; BIOLOGICAL EFFECTS; BODY; CARDIOVASCULAR DISEASES; DISEASES; HETEROCYCLIC COMPOUNDS; IMIDAZOLES; IMINES; INJURIES; MAMMALS; MEDICINE; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; RADIATION EFFECTS; RODENTS; SURGERY; SYMPTOMS; VASCULAR DISEASES; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals

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                    Juncos, L, Cornejo, J C, Cejas, H, and Broglia, C. Mechanisms of hypertension in renal radiation.  United States: N. p., 1990. 
        Web.  doi:10.1161/01.HYP.15.2_Suppl.I132.

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                    Juncos, L, Cornejo, J C, Cejas, H, & Broglia, C. Mechanisms of hypertension in renal radiation.  United States.  https://doi.org/10.1161/01.HYP.15.2_Suppl.I132

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                    Juncos, L, Cornejo, J C, Cejas, H, and Broglia, C. 1990.  
        "Mechanisms of hypertension in renal radiation".  United States.  https://doi.org/10.1161/01.HYP.15.2_Suppl.I132.

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@article{osti_7025195,

  title        = {Mechanisms of hypertension in renal radiation},

  author       = {Juncos, L and Cornejo, J C and Cejas, H and Broglia, C},

  abstractNote = {This study was undertaken to investigate the role played by renal functional and structural changes in the development of radiation-induced hypertension. Four groups of rats were studied: (1) left kidney radiated, (2) sham procedure, (3) uninephrectomy followed 3 weeks later by radiation of the contralateral kidney, and (4) uninephrectomy followed by sham procedure 3 weeks later. All radiated rats became hypertensive at 12 weeks (p less than 0.05) and had higher protein excretion (p less than 0.05). In the presence of an intact contralateral kidney, radiation causes mild-to-moderate histological abnormalities, and therefore, creatinine clearance and water and sodium handling do not change. Plasma renin activity increased in this group (p less than 0.05). Radiated uninephrectomized rats showed decreased creatinine clearance (p less than 0.05), but renin activity remained unchanged. These rats developed severe histological abnormalities in glomeruli, interstitia, tubuli, and vessels resulting in increased sodium and water output. The average of individual tubular and interstitial scores correlated significantly with both water intake and output but not with sodium excretion. These studies suggest that in the presence of an intact kidney, renin is an important determinant in the development or maintenance of radiation hypertension, whereas in the absence of the contralateral kidney, severe histological changes and renal failure are prominent despite increased water intake and output. The more severe glomerular sclerosis and proteinuria in the latter model could be related to diminished renal mass.},

  doi          = {10.1161/01.HYP.15.2_Suppl.I132},

  url          = {https://www.osti.gov/biblio/7025195},
  journal      = {Hypertension (Dallas); (USA)},

  issn         = {0194-911X},

  number       = ,

  volume       = 15:2 Suppl,

  place        = {United States},

  year         = {Thu Feb 01 00:00:00 EST 1990},

  month        = {Thu Feb 01 00:00:00 EST 1990}

}

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